1229571-92-9

Basic information

• Product Name: 4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridine-4-yl)-1,3-dihydro-2H-imidazol-2-one
• CAS NO: 1229571-92-9
• Molecular Weight: 340.4
• Mol File: 1229571-92-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridine-4-yl)-1,3-dihydro-2H-imidazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridine-4-yl)-1,3-dihydro-2H-imidazol-2-one(1229571-92-9)
• EPA Substance Registry System: 4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridine-4-yl)-1,3-dihydro-2H-imidazol-2-one(1229571-92-9)

Safety Data

• Hazardous Substances Data: 1229571-92-9(Hazardous Substances Data)

Upstream product

• 461-87-0 2-fluoro-4-methylpyridine 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 457081-00-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)-2-(hydroxyimino)-ethan-1-one 
• 302839-09-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)ethan-1-one 
• 581098-38-6 4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione 
• 598-74-3 2-amino-3-methylbutane 
• 1061602-00-3 2-(4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio)ethanol 

Relevant articles and documents

An optimized and versatile synthesis to pyridinylimidazole-type p38α mitogen activated protein kinase inhibitors

An optimized strategy for the synthesis of the potent p38α mitogen-activated protein kinase inhibitors 2-(2-hydroxyethylsulfanyl)-4-(4-fluorophenyl)-5-(2-aminopyridin-4-yl)imidazole (3) and 2-(2,3-dihydroxypropylsulfanyl)-4-(4-fluorophenyl)-5-(2-aminopyridin-4-yl)imidazole (4) starting from 2-fluoro-4-methylpyridine is reported. In contrast to a previously published synthesis starting from 2-bromo-4-methylpyridine, the overall yield could be increased from 3.6% to 29.4%. Moreover, this strategy avoids the use of palladium as a catalyst and is more diverse and versatile. Using this optimized protocol, both enantiomers of potent inhibitor 3 were synthesized. Biological data demonstrated that the (S)-enantiomer is the two times more potent eutomer.