1229593-79-6

Basic information

• Product Name: rhodamine-(AEEA)-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-NH₂; AEEA = 2-aminoethoxyethoxyacetyl spacer
• CAS NO: 1229593-79-6
• Molecular Weight: 1509.92
• Mol File: 1229593-79-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: rhodamine-(AEEA)-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-NH₂; AEEA = 2-aminoethoxyethoxyacetyl spacer(CAS DataBase Reference)
• NIST Chemistry Reference: rhodamine-(AEEA)-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-NH₂; AEEA = 2-aminoethoxyethoxyacetyl spacer(1229593-79-6)
• EPA Substance Registry System: rhodamine-(AEEA)-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-NH₂; AEEA = 2-aminoethoxyethoxyacetyl spacer(1229593-79-6)

Safety Data

• Hazardous Substances Data: 1229593-79-6(Hazardous Substances Data)

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 13734-41-3 t-Boc-L-valine 
• 13836-37-8 Boc-Arg(Tos)-OH 
• 54613-99-9 Boc-(S)-Lys(2-Cl-Z)-OH 
• 81-88-9 rhodamine B 
• 108466-89-3 N-(tert-butyloxycarbonyl)-8-amino-3,6-dioxaoctanoic acid 

Relevant articles and documents

A peptide nucleic acid embedding a pseudopeptide nuclear localization sequence in the backbone behaves as a peptide mimic

In this paper, the synthesis of a short modified peptide nucleic acid (PNA), obtained by using several different L-amino acids as synthons, is shown. The synthesis was performed by a submonomeric strategy, obtaining a model trimeric PNA containing embedded amino acid derived side chains in its backbone that mimic the peptide sequence PKKKRKV, which is a nuclear localization signal (NLS) widely used for translocating cargo molecules into cell nuclei. Fluorescence experiments demonstrated that this modified PNA, and not a standard unmodified PNA having the same nucleobase sequence, was able to penetrate Rhabdomyosarcoma cell nuclei, exactly behaving as the NLS standard peptide.