1230019-43-8

Basic information

• Product Name: 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid isoxazolo[5,4-c]pyridin-3-ylamide
• CAS NO: 1230019-43-8
• Molecular Weight: 463.923
• Mol File: 1230019-43-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid isoxazolo[5,4-c]pyridin-3-ylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid isoxazolo[5,4-c]pyridin-3-ylamide(1230019-43-8)
• EPA Substance Registry System: 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid isoxazolo[5,4-c]pyridin-3-ylamide(1230019-43-8)

Safety Data

• Hazardous Substances Data: 1230019-43-8(Hazardous Substances Data)

Upstream product

• 69770-20-3 3-(4-chlorophenoxy)benzaldehyde 
• 1229383-68-9 isoxazolo[5,4-c]pyridin-3-yl-carbamic acid phenyl ester 
• 1230021-77-8 tert-butyl 4-(3-(4-chlorophenoxy)benzyl)piperazine-1-carboxylate 
• 114080-94-3 isoxazolo[5,4-c]pyridin-3-amine 
• 68325-15-5 3-chloro-isonicotinonitrile 

Relevant articles and documents

Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure-mutagenicity relationships for arylamine metabolites

The structure-activity relationships for a series of heteroaryl urea inhibitors of fatty acid amide hydrolase (FAAH) are described. Members of this class of inhibitors have been shown to inactivate FAAH by covalent modification of an active site serine with subsequent release of an aromatic amine from the urea electrophile. Systematic Ames II testing guided the optimization of urea substituents by defining the structure-mutagenicity relationships for the released aromatic amine metabolites. Potent FAAH inhibitors were identified having heteroaryl amine leaving groups that were non-mutagenic in the Ames II assay.