1232344-37-4

Basic information

• Product Name: N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-2-thiopheneethanamine hydrochloride
• Synonyms: N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-2-thiopheneethanamine hydrochloride;2-ThiopheneethanaMine, N-propyl-N-[(2S)-1,2,3,4-tetrahydro-5-Methoxy-2-naphthalenyl]-, hydrochloride (1:1);(S)-5-methoxy-N-propyl-N-(2-(thiophen-2-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
• CAS NO: 1232344-37-4
• Molecular Formula: C20H28ClNOS
• Molecular Weight: 365.96042
• Mol File: 1232344-37-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-2-thiopheneethanamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-2-thiopheneethanamine hydrochloride(1232344-37-4)
• EPA Substance Registry System: N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-2-thiopheneethanamine hydrochloride(1232344-37-4)

Safety Data

• Hazardous Substances Data: 1232344-37-4(Hazardous Substances Data)

Usage

General Description

"N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-2-thiopheneethanamine hydrochloride" is a chemical compound that belongs to the class of thiopheneethanamine derivatives. It is a hydrochloride salt and is commonly used in pharmaceutical research and development. N-Propyl-N-[(2S)-1,2,3,4-tetrahydro-5-methoxy-2-naphthalenyl]-2-thiopheneethanamine hydrochloride has potential therapeutic applications due to its interaction with various receptors and enzymes in the central nervous system. Its molecular structure and properties make it a promising candidate for the development of new drugs for the treatment of neurological and psychiatric disorders. Further studies and clinical trials are needed to fully understand the pharmacological effects and potential uses of this chemical compound.

Upstream product

• 1232344-40-9 (-)-(S)-5-methoxy-2-[N-2-(2-thienyl)ethylamino]tetraline 
• 802294-64-0 propionic acid 
• 1148154-91-9 (2S)-5-methoxy-N-propyl-N-(2'-(thien-2-yl)ethyl)tetralin-2-amine 
• 107-08-4 1-iodo-propane 

Downstream Products

• 125572-93-2 rotigotine hydrochloride 
• 99755-59-6 rotigotine 

Relevant articles and documents

S-5-SUBSTITUENT-N-2'-(THIOPHENE-2-YL)ETHYL-TETRALIN-2-AMINE OR CHIRAL ACID SALTS THEREOF AND USE FOR PREPARING ROTIGOTINE

The chiral compound S-5-substituted-N-2′-(thienyl-2-yl-)ethyl-tetralin-2-amine or its chiral acid salts and preparation method thereof are disclosed, and the method for preparing Rotigotine by using the chiral compound is also disclosed. Racemic 5-substituted-N-2′-(thien-2-yl-)ethyl-tetralin-2-amine (compound 1) is resolved by using a conventional chiral acid to obtain an optically pure chiral acid salt of S-5-substituted-N-2′-(thien-2-yl-)ethyl-tetralin-2-amine, which is then dissociated to obtain S-5-substituted-N-2′-(thien-2-yl-)ethyl-tetralin-2-amine (compound 2). The compound 2 or chiral acid salt thereof is alkylated and deprotected to produce rotigotine (compound 5).

PROCESSES FOR PREPARING HIGHLY PURE ROTIGOTINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

Provided herein are convenient, industrially advantageous and environmentally friendly processes for the preparation of (?)-(S)-5-hydroxy-2-[N-n-propyl-N-2-(2-thienyl)ethylamino]tetralin (rotigotine) or a pharmaceutically acceptable salt thereof. Provided further herein is a highly pure rotigotine or a pharmaceutically acceptable salt thereof substantially free of impurities, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure rotigotine or a pharmaceutically acceptable salt thereof substantially free of impurities.