1232634-50-2Relevant articles and documents
Synthesis and molecular design of mono aspirinate thiourea-azo hybrid molecules as potential antibacterial agents
Ngaini, Zainab,Rasin, Ferlicia,Wan Zullkiplee, Wan Sharifatun H.,Abd Halim, Ainaa Nadiah
, p. 275 - 282 (2020)
New mono aspirinate thiourea-azo derivatives 2a–f were synthesized using aspirin as a natural product-based precursor, with 4-aminophenylazophenol derivatives in excellent 70–90% yields. Overall, 2a–f gave excellent antibacterial activity against Staphylo
Novel Synthetic Monothiourea Aspirin Derivatives Bearing Alkylated Amines as Potential Antimicrobial Agents
Nordin, Norsyafikah Asyilla,Chai, Tchan Wei,Tan, Bee Ling,Choi, Ching Liang,Abd Halim, Ainaa Nadiah,Hussain, Hasnain,Ngaini, Zainab
, (2017/02/19)
A new series of aspirin bearing alkylated amines moieties 1-12 were synthesised by reacting isothiocyanate with a series of aniline derivatives in overall yield of 16-56%. The proposed structures of all the synthesised compounds were confirmed using elemental analysis, FTIR, and 1H and 13C NMR spectroscopy. All compounds were evaluated for antibacterial activities against E. coli and S. aureus via turbidimetric kinetic and Kirby Bauer disc diffusion method. Compound 5 bearing meta -CH3 substituent showed the highest relative inhibition zone diameter against tested bacteria compared to ortho and para substituent. Furthermore, aspirin derivatives bearing shorter chains exhibited better bacterial inhibition than longer alkyl chains.
Efficient synthesis of new (R)-2-amino-1-butanol derived ureas, thioureas and acylthioureas and in vitro evaluation of their antimycobacterial activity
Dobrikov, Georgi M.,Valcheva, Violeta,Nikolova, Yana,Ugrinova, Iva,Pasheva, Evdokia,Dimitrov, Vladimir
supporting information, p. 468 - 473 (2013/07/25)
The synthesis of 22 structurally diverse urea, thiourea and acylthiourea derivatives containing the (R)-2-amino-1-butanol motif has been performed. The evaluation of their in vitro activity against Mycobacterium tuberculosis (H 37Rv and strain
