123285-52-9

Basic information

• Product Name: 2-(S)-[N-(tert-butoxycarbonyl)amino]-3-methylbutanal
• Synonyms: 2-(S)-[N-(tert-butoxycarbonyl)amino]-3-methylbutanal
• CAS NO: 123285-52-9
• Molecular Weight: 201.266
• Mol File: 123285-52-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-(S)-[N-(tert-butoxycarbonyl)amino]-3-methylbutanal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(S)-[N-(tert-butoxycarbonyl)amino]-3-methylbutanal(123285-52-9)
• EPA Substance Registry System: 2-(S)-[N-(tert-butoxycarbonyl)amino]-3-methylbutanal(123285-52-9)

Safety Data

• Hazardous Substances Data: 123285-52-9(Hazardous Substances Data)

Upstream product

• 169556-48-3 rac-tert-butyl (1-hydroxy-3-methylbutan-2-yl)carbamate 
• 13734-41-3 N-Boc-(S/R)-valine 
• 293329-55-2 tert-butyl 1-(methoxy(methyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate 
• 6306-52-1 L-valine methylester hydrochloride 
• 72-18-4 L-valine 
• 516-06-3 D,L-valine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 16369-05-4 valinol 
• 58561-04-9 N-Boc-valine methyl ester 

Downstream Products

• 1435915-21-1 C₂₅H₂₇N₃O₆S 
• 1435915-78-8 C₂₅H₂₉N₃O₆S 
• 1257438-12-2 α-[2,2-bis(phenylsulfonyl)ethyl]-α-(tert-butoxycarbonylamino)-β-methylbutanal 
• 731859-50-0 2-isopropyl-5-(9-phenyl-9H-fluoren-9-yl)-5,6-dihydro-4H-pyrrolo[3,4-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 

Relevant articles and documents

Chemo- and Diastereoselective N-Heterocyclic Carbene-Catalyzed Cross-Benzoin Reactions Using N-Boc-α-amino Aldehydes

N-Boc-α-amino aldehydes are shown to be excellent partners in cross-benzoin reactions with aliphatic or heteroaromatic aldehydes. The chemoselectivity of the reaction and the facial selectivity on the amino aldehyde allow cross-benzoin products to be obtained in good yields and good diastereomeric ratios. The developed method is utilized as the key step in a concise total synthesis of d-arabino-phytosphingosine.

Efficient Entropy-Driven Inhibition of Dipeptidyl Peptidase III by Hydroxyethylene Transition-State Peptidomimetics

Dipeptidyl peptidase III (DPP3) is a ubiquitously expressed Zn-dependent protease, which plays an important role in regulating endogenous peptide hormones, such as enkephalins or angiotensins. In previous biophysical studies, it could be shown that substr

Synthesis of proline analogues as potent and selective cathepsin S inhibitors

Cathepsin S is a potential target of autoimmune disease. A series of proline derived compounds were synthesized and evaluated as cathepsin S inhibitors. We discovered potent cathepsin S inhibitors through structure-activity relationship studies of proline analogues. In particular, compound 19-(S) showed promising in vitro/vivo pharmacological activities and properties as a selective cathepsin S inhibitor.