1233087-03-0Relevant articles and documents
Metal-Free Insertion of Sulfoxonium Ylides into Arylamines in Water
He, Hua,Yan, Kaichuan,Li, Jianglian,Lai, Ruizhi,Luo, Yi,Guan, Mei,Wu, Yong
, p. 3065 - 3070 (2020/08/10)
Carbenoid-based N-H insertions have undergone significant development with respect to C-N bond formation in recent years. However, the existing methods suffer from unstable starting materials, expensive metal catalysts and organic solvents. Herein, insertion of sulfoxonium ylides into arylamines under metal-free conditions has been developed. The method employs water as solvent at mild temperature and is amenable to the late-stage modification of structurally complex bioactive compounds.