1233201-81-4Relevant articles and documents
Ugi reaction for the synthesis of 4-aminopiperidine-4-carboxylic acid derivatives. Application to the synthesis of carfentanil and remifentanil
Malaquin, Sandra,Jida, Mouhamad,Gesquiere, Jean-Claude,Deprez-Poulain, Rebecca,Deprez, Benoit,Laconde, Guillaume
experimental part, p. 2983 - 2985 (2010/07/06)
A two-step sequence involving an Ugi four-component reaction was developed for the preparation of 4-aminopiperidine-4-carboxylic acid derivatives. This strategy has led to the successful preparation of two drugs carfentanil and remifentanil in shorter times and better yields than previously described methods.
