1233501-57-9 Usage
Description
4-ethynyl-3-fluorobenzenaMine, with the molecular formula C8H5FN, is a chemical compound that serves as a versatile building block in the synthesis of pharmaceuticals and organic compounds. Characterized by its strong electron-withdrawing properties, this compound is highly reactive and finds applications across various fields, including medicine, material science, and organic chemistry. Due to its potential hazards if mishandled, careful handling is essential.
Uses
Used in Pharmaceutical Synthesis:
4-ethynyl-3-fluorobenzenaMine is used as a key intermediate in the synthesis of various pharmaceuticals, leveraging its strong electron-withdrawing properties to facilitate a range of organic reactions that contribute to the development of new drugs.
Used in Organic Chemistry:
In the realm of organic chemistry, 4-ethynyl-3-fluorobenzenaMine is utilized as a ligand in catalysts, enabling a variety of chemical transformations that are crucial for the advancement of organic synthesis techniques.
Used in Material Science:
4-ethynyl-3-fluorobenzenaMine's unique properties also make it a valuable component in the field of material science, where it can be incorporated into the development of new materials with specific properties tailored for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1233501-57-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,3,5,0 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1233501-57:
(9*1)+(8*2)+(7*3)+(6*3)+(5*5)+(4*0)+(3*1)+(2*5)+(1*7)=109
109 % 10 = 9
So 1233501-57-9 is a valid CAS Registry Number.
1233501-57-9Relevant articles and documents
General and efficient synthesis of polyfluorinated 2-aminotolans and 2-arylindoles
Politanskaya, Larisa V.,Shteingarts, Vitalij D.,Tretyakov, Evgeny V.
, p. 85 - 98 (2016)
It was established here that cross-coupling of polyfluorinated 2-iodoanilines with arylacetylenes in MeCN in the presence catalytic amounts of Pd(PPh3)2Cl2, CuI and Et3N produces the corresponding 2-aminotolans although their yields are decreased from 98% to 40% with increasing fluorination of the substrates. It was shown that the 2-aminotolans with six or fewer fluorine atoms in their rings can be heterocyclised by heating in ethanol containing p-TSA to produce the corresponding polyfluorinated indoles. Cyclisation of tolans containing larger numbers of fluorine atoms in their rings proceeds most efficiently in the presence of KOH, resulting in 2-phenylindoles containing the current maximum of eight fluorine atoms.
