1233503-36-0Relevant articles and documents
Pd-catalyzed C-N bond formation with heteroaromatic tosylates
Mantel, Mette L. H.,Lindhardt, Anders T.,Lupp, Daniel,Skrydstrup, Troeis
supporting information; experimental part, p. 5437 - 5442 (2010/09/18)
A protocol for the palladium(0)-catalyzed amidation of heteroaromatic tosylates was successfully developed. The methodology proved to be effective for a variety of heteroaryl tosylates including the pyridine, pyrimidine, quinoline and quinoxaline ring systems. Successful carbon-nitrogen bond formation with these heteroaryl tosylates could be performed with a wide range of primary amides, oxazolidinones, lactams, anilines and indoles, including one cyclic urea. Moreover, this C-N bond forming reaction provided products with high structural diversity. The coupling reaction was also amenable to scale up applications.