1233510-32-1

Basic information

• Product Name: (+)-(R)-5-[(S)-(4-bromophenyl)hydroxymethyl]furan-2(5H)-one
• Synonyms: (+)-(R)-5-[(S)-(4-bromophenyl)hydroxymethyl]furan-2(5H)-one
• CAS NO: 1233510-32-1
• Molecular Weight: 269.095
• Mol File: 1233510-32-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (+)-(R)-5-[(S)-(4-bromophenyl)hydroxymethyl]furan-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(R)-5-[(S)-(4-bromophenyl)hydroxymethyl]furan-2(5H)-one(1233510-32-1)
• EPA Substance Registry System: (+)-(R)-5-[(S)-(4-bromophenyl)hydroxymethyl]furan-2(5H)-one(1233510-32-1)

Safety Data

• Hazardous Substances Data: 1233510-32-1(Hazardous Substances Data)

Upstream product

• 497-23-4 2-buten-4-olide 
• 1122-91-4 4-bromo-benzaldehyde 
• 121896-38-6 2-tert-butyldimethylsilyloxyfuran 
• 61550-02-5 (furan-2-yloxy)-trimethylsilane 

Relevant articles and documents

Squaramide-Sulfonamide Organocatalyst for Asymmetric Direct Vinylogous Aldol Reactions

Asymmetric direct vinylogous aldol reactions of furan-2(5H)-one with aldehydes in the presence of a catalytic amount of novel squaramide-sulfonamide organocatalyst resulted in the corresponding addition products with high to excellent enantioselectivities. This is the first successful report illustrating an example of highly stereoselective reactions using a squaramide-sulfonamide organocatalyst.

Asymmetric direct vinylogous aldol reaction of unactivated γ-butenolide to aldehydes

(Figure presented) The asymmetric direct vinylogous aldol reaction of unactivated γ-butenolide with aldehydes has been developed, giving the corresponding 5-(1′-hydroxy)butenolide derivatives in high yields (up to 93%) and enantioselectivities (up to 83%

Asymmetric vinylogous aldol reaction of silyloxy furans with a chiral organic salt

Despite their synthetic significance there is a general lack of asymmetric vinylogous aldol reactions that tolerate variations of both the silyloxy furans and aldehydes. We have developed a new chiral organic catalyst based on a carboxylate-ammonium salt prepared from a thiourea-amine and a carboxylic acid. This new catalyst enabled us to develop an efficient asymmetric vinylogous aldol reaction of unprecedented scope with respect to both 2-trimethylsilyloxy furans and aldehydes.