123387-72-4

Basic information

• Product Name: N-BOC-(METHYLAMINO)ACETALDEHYDE
• Synonyms: tert-Butyl N-methyl-N-(2-oxoethyl)carbamate;N-(tert-butoxycarbonyl)-N-MethylaMinoacetaldehyde;N-Boc-2-(methylamino)acetaldehyde;N-BOC-(METHYLAMINO)ACETALDEHYDE;N-methyl-N-(2-oxoethyl)-, 1,1-dimethylethyl ester;O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate;N-tert-Butoxycarbonyl-(methylamino)acetaldehyde
• CAS NO: 123387-72-4
• Molecular Formula: C₈H₁₅NO₃
• Molecular Weight: 173.21
• Product Categories: Indolines ,Indoles
• Mol File: 123387-72-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 218.2°Cat760mmHg
• Flash Point: 85.8°C
• Appearance: /
• Density: 1.026g/cm³
• Vapor Pressure: 0.127mmHg at 25°C
• Refractive Index: 1.443
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -1.63±0.70(Predicted)
• Water Solubility: Slightly miscible with water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: N-BOC-(METHYLAMINO)ACETALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-(METHYLAMINO)ACETALDEHYDE(123387-72-4)
• EPA Substance Registry System: N-BOC-(METHYLAMINO)ACETALDEHYDE(123387-72-4)

Safety Data

• Hazardous Substances Data: 123387-72-4(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

N-Boc-(methylamino)acetaldehyde is involved in the preparation of benzo[d]imidazole inhibitor of co-activator associated arginine methyltransferase.

InChI:InChI=1/C8H15NO3/c1-8(2,3)12-7(11)9(4)5-6-10/h6H,5H2,1-4H3

Upstream product

• 42492-57-9 methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate 

Downstream Products

• 1027168-88-2 (S)-2-((S)-1-Benzyloxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-6-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-hexanoic acid benzyl ester 
• 913963-45-8 1,1-dimethylethyl {2-{{(1S)-1-[(diphenylphosphino)methyl]-2-methylpropyl}amino}ethyl}methylcarbamate 
• 187480-23-5 N'-tert-butoxycarbonyl-N'-methyl-N-(3-methylbenzyl)ethylenediamine 
• 912971-35-8 tert-butyl 2-(4-(2-(2-methoxyphenyl)-1H-indol-5-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl(methyl)carbamate 
• 912971-43-8 tert-butyl 2-(4-(2-(2-methoxyphenyl)-1H-indol-5-yl)piperidin-1-yl)ethyl(methyl)carbamate 
• 912971-27-8 tert-butyl 2-(4-(4-amino-3-nitrophenyl)piperidin-1-yl)ethyl(methyl)carbamate 
• 912971-52-9 (E)-tert-butyl 2-(4-(2-(2-methoxyphenyl)-1H-indol-5-yl)-2,3,6,7-tetrahydro-1H-azepin-1-yl)ethyl(methyl)carbamate 
• 912971-55-2 tert-butyl 2-(10-(2-(2-methoxyphenyl)-1H-indol-5-yl)-7-azaspiro[4.5]dec-9-en-7-yl)ethyl(methyl)carbamate 
• 912971-57-4 tert-butyl 2-(3-(2-(2-methoxyphenyl)-1H-indol-5-yl)-8-azabicyclo[3.2.1]oct-3-en-8-yl)ethyl(methyl)carbamate 
• 912971-59-6 tert-butyl 2-(3-(2-(2-methoxyphenyl)-1H-indol-5-yl)-2,5-dihydro-1H-pyrrol-1-yl)ethyl(methyl)carbamate 
• 912971-61-0 tert-butyl 2-(4-(2-(2-methoxyphenyl)-1H-indol-5-yl)-5,5-dimethyl-5,6-dihydropyridin-1(2H)-yl)ethyl(methyl)carbamate 
• 912971-64-3 tert-butyl 2-(4-(2-(2-chlorophenyl)-1H-indol-5-yl)piperidin-1-yl)ethyl(methyl)carbamate 
• 912971-68-7 tert-butyl methyl(2-(4-(2-(2-(methylsulfonamido)phenyl)-1H-indol-5-yl)piperidin-1-yl)ethyl)carbamate 
• 912971-31-4 tert-butyl 2-(4-(4-amino-5-methyl-3-nitrophenyl)piperidin-1-yl)ethyl-(methyl)carbamate 

Relevant articles and documents

Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues

The antimitotic sponge tripeptide hemiasterlin (1) and a number of structural analogues have been synthesized and evaluated in cell-based assays for both cytotoxic and antimitotic activity in order to explore the SAR for this promising anticancer drug lead. One synthetic analogue, SPA110 (8), showed more potent in vitro cytotoxicty and antimitotic activity than the natural product hemiasterlin (1), and consequently it has been subjected to thorough preclinical evaluation and targeted for clinical evaluation. The details of the synthesis of hemiasterlin (1) and the analogues and a discussion of how their biological activities vary with their structures are presented in this paper.