1234015-66-7

Basic information

• Product Name: tert-butyl (3-(2-(3-((5-cyanopyrazin-2-yl)amino)-1H-pyrazol-5-yl)-3-methoxyphenoxy)propyl)carbamate
• Synonyms: tert-butyl (3-(2-(3-((5-cyanopyrazin-2-yl)amino)-1H-pyrazol-5-yl)-3-methoxyphenoxy)propyl)carbamate
• CAS NO: 1234015-66-7
• Molecular Weight: 465.512
• Mol File: 1234015-66-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl (3-(2-(3-((5-cyanopyrazin-2-yl)amino)-1H-pyrazol-5-yl)-3-methoxyphenoxy)propyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (3-(2-(3-((5-cyanopyrazin-2-yl)amino)-1H-pyrazol-5-yl)-3-methoxyphenoxy)propyl)carbamate(1234015-66-7)
• EPA Substance Registry System: tert-butyl (3-(2-(3-((5-cyanopyrazin-2-yl)amino)-1H-pyrazol-5-yl)-3-methoxyphenoxy)propyl)carbamate(1234015-66-7)

Safety Data

• Hazardous Substances Data: 1234015-66-7(Hazardous Substances Data)

Upstream product

• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 
• 1234015-69-0 5-(5-(2-hydroxy-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile 
• 1234015-70-3 5-(5-(2-hydroxy-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile dihydrogen chloride 
• 557-21-1 zinc(II) cyanide 
• 1234015-65-6 tert-butyl 3-(2-(3-(5-bromopyrazin-2-ylamino)-1H-pyrazol-5-yl)-3-methoxyphenoxy)propylcarbamate 
• 113305-94-5 2-amino-5-cyanopyrazine 
• 703-23-1 2'-hydroxy-6'-methoxyacetophenone 
• 1234015-62-3 1-(2-methoxy-6-((4-methoxyphenyl)methoxy)phenyl)-3,3-bis(methylsulfonyl)-2-propen-1-one 
• 1234015-67-8 5-(((E)-3-(2-methoxy-6-((4-methoxyphenyl)methoxy)phenyl)-1-methylsulfonyl-3-oxo-1-propenyl)amino)pyrazine-2-carbonitrile 
• 1234015-68-9 5-((5-(2-methoxy-6-((4-methoxyphenyl)methoxy)phenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile 
• 1234015-63-4 5-bromo-N-(5-(2-methoxy-6-(4-methoxybenzyloxy)phenyl)-1H-pyrazol-3-yl)pyrazin-2-amine 
• 1234015-64-5 2-(3-(5-bromopyrazin-2-ylamino)-1H-pyrazol-5-yl)-3-methoxyphenol 
• 36070-75-4 5-chloro-2-pyrazinecarbonitrile 

Downstream Products

• 1234015-52-1 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile 
• 1234015-55-4 5-(5-(2-(3-aminopropoxy)-6-ethoxvphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile methanesulfonic acid 

Relevant articles and documents

5-(5-(2-(3-AMINOPROPOXY)-6-METHOXYPHENYL)-1H-PYRAZOL-3-YLAMINO)PYRAZINE-2-CARBONITRILE (S)-LACTATE MONOHYDRATE

The disclosure herein includes 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H- pyrazol-3-ylamino)pyrazine-2-carbonitrile (S)-lactate monohydrate that inhibits Chk1/2 and is useful in the treatment of cancer.

COMPOUNDS USEFUL FOR INHIBITING CHK1

The present invention provides an aminopyrazole compound, or a pharmaceutically acceptable salt thereof or a solvate of the salt, that inhibits Chk1 and is useful in the treatment of cancer.