123418-69-9

Basic information

• Product Name: 5-broMo-4-chlorothiophene-2-carboxylic acid
• Synonyms: 5-broMo-4-chlorothiophene-2-carboxylic acid;5-BroMo-4-chloro-2-thiophenecarboxylic acid
• CAS NO: 123418-69-9
• Molecular Formula: C₅H₂BrClO₂S
• Molecular Weight: 241.49018
• Mol File: 123418-69-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 348.0±42.0 °C(Predicted)
• Appearance: /
• Density: 2.019±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.31±0.10(Predicted)
• CAS DataBase Reference: 5-broMo-4-chlorothiophene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-4-chlorothiophene-2-carboxylic acid(123418-69-9)
• EPA Substance Registry System: 5-broMo-4-chlorothiophene-2-carboxylic acid(123418-69-9)

Safety Data

• Hazardous Substances Data: 123418-69-9(Hazardous Substances Data)

Usage

General Description

5-bromo-4-chlorothiophene-2-carboxylic acid is a chemical compound with the molecular formula C6H3BrClO2S. It is a heterocyclic compound that contains a thiophene ring with bromine, chlorine, and carboxylic acid functional groups attached. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of various organic compounds and materials. The compound is a white to off-white crystalline powder with a melting point of around 122-125°C. It must be handled with care as it can cause skin and eye irritation, and it should be stored in a cool, dry place.

Upstream product

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• 88-15-3 2-Acetylthiophene 
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• 34730-20-6 1-(4-chlorothiophen-2-yl)ethan-1-one 
• 59614-95-8 4-Chloro-2-thiophenecarboxylic Acid 

Relevant articles and documents

PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS

This disclosure generally relates to pyridine-2-one compounds of formula (I) and methods of using them in the treatment of a disorder, such as cancer or a SMARCA2-associated disorder, including as antagonists (e.g., inhibitors) of SMARCA2. The present disclosure provides treatment modalities, e.g., strategies, treatment methods, patient stratification methods, compounds, combinations, and compositions that are useful for the treatment of disorders, e.g., proliferative disorders, such as certain cancers. Some aspects of this disclosure provide treatment modalities, methods, strategies, compounds, compositions, combinations, and dosage forms for the treatment of cell proliferative disorders, e.g., cancers with decreased activity or function, or loss of function, of SMARCA4 with a SMARCA2 antagonist.

NAMPT inhibitors

Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

Herbicidal Thienylureas, I

Syntheses of the title substances as potential herbicides are described by a modified Curtius degradation of corresponding thiophene carboxylic acids, obtained in turn by haloform reaction of appropriate acetyl thiophenes.Regioselective substitution reactions of thiophenes were key steps for the construction of desired substitution patterns.Structure-activity considerations show that especially the 3-thienyl ureas 36 and 38 exhibit significant herbicidal activity comparable with commercial products. - Keywords: Curtius degradation; Herbicides; Thiophenes; Ureas; Urethanes