1234312-47-0

Basic information

• Product Name: Br^(1-)*C₆₃H₁₀₁N₆O₈⁽¹⁺⁾
• CAS NO: 1234312-47-0
• Molecular Weight: 1150.43
• Mol File: 1234312-47-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Br^(1-)*C₆₃H₁₀₁N₆O₈⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: Br^(1-)*C₆₃H₁₀₁N₆O₈⁽¹⁺⁾(1234312-47-0)
• EPA Substance Registry System: Br^(1-)*C₆₃H₁₀₁N₆O₈⁽¹⁺⁾(1234312-47-0)

Safety Data

• Hazardous Substances Data: 1234312-47-0(Hazardous Substances Data)

Upstream product

• 1234312-43-6 C₃₂H₅₀N₂O₂ 
• 257280-68-5 1-bromomethyl-4-(4,7,10-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane-1-ylmethyl)benzene 
• 3464-50-4 chloroacetic acid cholesterylester 

Relevant articles and documents

Novel cationic lipids possessing protonated cyclen and imidazolium salt for gene delivery

In this study, two novel protonated cyclen and imidazolium salt-containing cationic lipids differing only in their hydrophobic region (cholesterol or diosgenin) have been designed and synthesized for gene delivery. Cationic liposomes were easily prepared from each of these lipids individually or from the mixtures of each cationic lipid and dioleoylphosphatidyl ethanolamine (DOPE). Several studies including DLS, gel retardation assay, ethidium bromide intercalation assay, and TEM demonstrated that these amphiphilic molecules are able to bind and compact DNA into nanometer particles that could be used as non-viral gene delivery agents. Our results from in vitro transfection showed that in association with DOPE, two cationic lipids can induce effective gene transfection in HEK293 cells. Furthermore, the gene transfection efficiencies of two cationic lipids were dramatically increased in the presence of calcium ion (Ca2+). It is notable that the gene transfection abilities of two cationic lipids were maintained in the presence of 10% serum. Besides, different cytotoxicity was found for two lipoplexes. This study demonstrates that the title cationic lipids have large potential to be efficient non-viral gene vector.