1234321-81-3

Basic information

• Product Name: Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate
• Synonyms: Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate;(Z)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate;(2Z)-3-(Acetylamino)-4-(2,4,5-trifluorophenyl)-2-butenoic acid methyl ester
• CAS NO: 1234321-81-3
• Molecular Formula: C₁₃H₁₂F₃NO₃
• Molecular Weight: 287.2344896
• EINECS: -0
• Mol File: 1234321-81-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 436.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.304±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.58±0.46(Predicted)
• CAS DataBase Reference: Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate(1234321-81-3)
• EPA Substance Registry System: Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate(1234321-81-3)

Safety Data

• Hazardous Substances Data: 1234321-81-3(Hazardous Substances Data)

Usage

General Description

Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate is a chemical compound with the molecular formula C14H14F3NO3. It is a synthetic organic compound that is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is a pale yellow solid at room temperature and is insoluble in water but soluble in organic solvents. Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate is used in the production of various drugs and has potential applications in the field of medicinal chemistry and drug discovery. Additionally, it is commonly used as a reagent in chemical research and synthesis.

Upstream product

• 881995-70-6 (2Z)-3-amino-4-(2,4,5-trifluorophenyl)but-2-enoic acid methyl ester 
• 108-24-7 acetic anhydride 
• 769195-26-8 4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester 
• 60-35-5 acetamide 
• 67-56-1 methanol 
• 631-61-8 ammonium acetate 
• 764667-64-3 5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 

Downstream Products

• 1234321-83-5 (R)-methyl-3-N-acetylamino-4-(2,4,5-trifluorophenyl)butanoate 
• 486460-00-8 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 
• 486460-23-5 (R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 486460-32-6 sitagliptin 

Relevant articles and documents

Recycling method of acetyl Meldrum's acid derivative degradation waste

The invention provides a recycling method of acetyl Meldrum's acid derivative degradation waste, and belongs to the technical field of resource reutilization. According to the method disclosed by the invention, acetyl Meldrum's acid derivative degradation waste is subjected to preheating treatment, alcoholysis reaction, ammonolysis reaction, acetylation reaction and purification treatment, the main components in theacetyl Meldrum's acid derivative degradation waste are converted, and a recovery product is finally obtained and can be used as an important intermediate in a sitagliptin production process, so that waste resource reutilization in the production process of the sitagliptin bulk drug is realized, economic loss caused by degradation of the acetyl Meldrum's acid derivative in the production process of the sitagliptin bulk drug is reduced, the problem of environmental pollution caused by degradation of the acetyl Meldrum's acid derivative in the production process of the sitagliptin bulk drug is eliminated, and the sustainable development of a sitagliptin raw material medicine green pharmaceutical process is promoted.

Highly efficient and facile synthesis of β-enaminones catalyzed by diphenylammonium triflate

Abstract: The catalytic performance of diphenylammonium triflates as an organocatalyst in the synthesis of β-enaminones from various substituted β-diketones and amides (or amines) were evaluated. A wide range of β-enaminones were efficiently synthesized in good to excellent yields under mild reaction conditions. Applying diphenylammonium triflate (DPAT) as catalyst makes this protocol cost-effective, low corrosive and easy to handle. Graphic abstract: [Figure not available: see fulltext.].