123436-08-8Relevant articles and documents
The cytochrome: C -cyclo[6]aramide complex as a supramolecular catalyst in methanol
Pan, Wang,Mao, Lijun,Shi, Mingsong,Fu, Yonghong,Jiang, Xiaomin,Feng, Wen,He, Youzhou,Xu, Dingguo,Yuan, Lihua
, p. 3857 - 3866 (2018)
A hydrogen-bonded macrocycle, cyclo[6]aramide, was found to form a supramolecular complex with cytochrome c, which enables the solubilization of the heme protein in methanol. The supramolecular complexation was evidenced by UV-vis, CD, and Raman spectroscopic techniques via structural characterization. Computational simulation based on the DFT method reveals the presence of strong hydrogen bonds formed between the lysine residues exposed on the protein surface and the oxygen atoms residing in the cavity of cyclo[6]aramide apart from cation-π interactions. The resulting cytochrome c-cyclo[6]aramide 1 exhibited higher activities than unmodified cytochrome c in the oxidation of benzhydrol to benzophenone with hydrogen peroxide at low temperatures. The enhanced activity with lowering temperature up to -40 °C indicates that the complex can act as a "cold-active" synzyme. The results achieved here demonstrate the potential of hydrogen-bonded macrocycles in supramolecular chemistry for catalytic reactions via ligand-protein interactions.
Isosterically designed chiral catalysts: Rationale, optimization and their application in enantioselective nucleophilic addition to aldehydes
Gao, En,Li, Qiao,Duan, Lili,Li, Lin,Li, Yue-Ming
supporting information, (2020/10/20)
Proline-based N,N′-dioxide ligands were designed on the basis of isosteric approach, and were successfully applied in enantioselective nucleophilic addition to aldehydes. In the presence of 10 mol% of chiral ligand 1b, enantioselective addition of diethylzinc to aldehydes provided the corresponding secondary alcohols in up to 90% isolated yield and up to 99% ee. Similarly, using 3e as chiral ligand, enantioselective arylation and alkynylation of aldehydes also proceeded readily, leading to the desired chiral alcohols in up to 92% isolated yield at 99% ee and 80% isolated yields and up to 84% ee, respectively. The current work would shed light on expanding the structure diversity in the design of chiral ligands and chiral catalysts.
Development of Chiral C2-Symmetric N-Heterocyclic Carbene Rh(I) Catalysts through Control of Their Steric Properties
Abadie, Marc-Antoine,Macintyre, Kirsty,Boulho, Cédric,Hoggan, Peter,Capet, Frédéric,Agbossou-Niedercorn, Francine,Michon, Christophe
, p. 536 - 543 (2019/01/14)
Chiral square-planar Rh(I) complexes based on new C2-symmetric NHC ligands have been synthesized selectively in a few steps as single diastereoisomers. These chiral precatalysts were applied to the asymmetric transfer hydrogenation of 1-phenylp
