1234564-87-4Relevant articles and documents
Room temperature, copper-catalyzed amination of bromonaphthyridines with aqueous ammonia
Anderson, Cyrus A.,Taylor, Phillip G.,Zeller, Mary A.,Zimmerman, Steven C.
supporting information; experimental part, p. 4848 - 4851 (2010/10/20)
(Figure Presented) Room temperature, copper-catalyzed amination of amido-bromo-1,8-naphthyridines is reported. Use of Cu2O and aqueous ammonia at ambient temperature affords amination products in 10-87% yield. Bromonaphthyridines are prepared in 15-65% yield via treatment of amidonaphthyridinones with phosphorus tribromide. This methodology provides an alternative route to functional, nonsymmetric 2,7-diamido-1,8-naphthyridines.