1234703-40-2

Basic information

• Product Name: LY-2608204
• Synonyms: LY-2608204;(1R,2S)-2-Cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]cyclopropanecarboxamide;(1R,2S)-2-cyclohexyl-1-(4-(cyclopropylsulfonyl)phenyl)-N-(5-((2-(pyrrolidin-1-yl)ethyl)thio)thiazol-2-yl)cyclopropanecarboxaMide;(1R,2S)-2-Cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]cyclopropanecarboxamide LY 2608204
• CAS NO: 1234703-40-2
• Molecular Formula: C₂₈H₃₇N₃O₃S₃
• Molecular Weight: 559.80668
• Product Categories: Inhibitors
• Mol File: 1234703-40-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.35
• Solubility: ≥28.35 mg/mL in DMSO; insoluble in H2O; ≥26.2 mg/mL in EtOH
• CAS DataBase Reference: LY-2608204(CAS DataBase Reference)
• NIST Chemistry Reference: LY-2608204(1234703-40-2)
• EPA Substance Registry System: LY-2608204(1234703-40-2)

Safety Data

• Hazardous Substances Data: 1234703-40-2(Hazardous Substances Data)

Usage

Description

LY-2608204 is an activator of glucokinase (GK), a key enzyme involved in glucose metabolism. It has been shown to stimulate glucose metabolism in INS-1E rat insulinoma cells and effectively decrease plasma glucose levels in fasted rats in a dose-dependent manner.

Uses

Used in Pharmaceutical Industry:
LY-2608204 is used as a therapeutic agent for the treatment of diabetes. Its ability to activate glucokinase and stimulate glucose metabolism makes it a promising candidate for managing blood sugar levels and improving overall glucose homeostasis in diabetic patients.
Used in Research and Development:
LY-2608204 is also used as a research tool in the study of glucose metabolism and the role of glucokinase in various cellular processes. It can help researchers better understand the mechanisms underlying diabetes and develop new strategies for its treatment and prevention.

references

[1] kj filipski, bd stevens . glucokinase activators in development .2012 books

Upstream product

• 1042777-99-0 5-(2-pyrrolidin-1-yl-ethylsulfanyl)-thiazol-2-ylamine 

Relevant articles and documents

CYCLOPROPYL COMPOUNDS

A compound of the formula: and pharmaceutical compositions for the treatment of diabetes.