123484-22-0

Basic information

• Product Name: 6-deoxy-β-D-allose
• Synonyms: 6-deoxy-β-D-allose
• CAS NO: 123484-22-0
• Molecular Weight: 164.158
• Mol File: 123484-22-0.mol
• Article Data: 33

Chemical Properties

• CAS DataBase Reference: 6-deoxy-β-D-allose(CAS DataBase Reference)
• NIST Chemistry Reference: 6-deoxy-β-D-allose(123484-22-0)
• EPA Substance Registry System: 6-deoxy-β-D-allose(123484-22-0)

Safety Data

• Hazardous Substances Data: 123484-22-0(Hazardous Substances Data)

Upstream product

• 107091-09-8 3-O-β-D-galactopyranosyl-(1->2)-<β-D-xylopyranosyl-(1->3)>-β-D-glucuronopyranosyl quillaic acid 28-O-β-D-apiofuranosyl-(1->3)-β-D-xylopyranosyl-(1->4)-<β-D-glucopyranosyl-(1->3)>-α-L-rhamnopyranosyl-(1->2)-β-D-fucopyranoside. 
• 38971-41-4 25(S)-ruscogenin 1-O-α-L-rhamnopyranosyl-(1->2)-β-D-fucopyranoside 
• 87425-34-1 25(S)-ruscogenin 1-O-β-D-fucopyranosido-3-O-α-L-rhamnopyranoside 
• 77174-32-4 Zizyphus saponin I 
• 55466-05-2 Zizyphus saponin III 
• 6130-58-1 kaempferol-3-rutinoside 
• 865688-88-6 quercitrin 
• 1033607-50-9 chrysin 4'-O-α-D-6-deoxyallopyranoside 
• 546-02-1 coroglaucigenin 3-O-(6-deoxy-β-D-allopyranoside) 

Downstream Products

• 65310-00-1 (3S,4R,5S,6S)-2-methoxy-6-methyltetrahydro-2H-pyran-3,4,5-triol 
• 57472-03-4 methyl β-L-fucofuranoside 
• 57472-02-3 methyl α-L-fucofuranoside 
• 14687-15-1 methyl L-fucopyranoside 
• 1128-40-1 methyl β-L-fucopyranoside 
• 1128-40-1 methyl 6-deoxy-β-D-galactopyranoside 
• 1128-40-1 methyl α-D-fucopyranoside 
• 80483-13-2 2,3,4-tri-O-acetyl-L-fucopyranosyl bromide 
• 5328-43-8 1-deoxy-L-galactitol 
• 52628-69-0 2,4-dinitrophenyl-6-deoxy-β-D-galactopyranoside 
• 176776-17-3 benzyl L-fucopyranoside 
• 78120-06-6 benzyl β-D-fucopyranoside 
• 167990-42-3 3-(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-1-propene 
• 181629-25-4 2-(tri-O-benzyl-α-L-fucopyranosyl)ethylamine 

Relevant articles and documents

Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea

Triple-negative breast cancers (TNBC) are aggressive and heterogeneous cancers that lack targeted therapies. We implemented a screening program to identify new leads for subgroups of TNBC using diverse cell lines with different molecular drivers. Through this program, we identified an extract from Calotropis gigantea that caused selective cytotoxicity in BT-549 cells as compared to four other TNBC cell lines. Bioassay-guided fractionation of the BT-549 selective extract yielded nine cardenolides responsible for the selective activity. These included eight known cardenolides and a new cardenolide glycoside. Structure-activity relationships among the cardenolides demonstrated a correlation between their relative potencies toward BT-549 cells and Na+/K+ ATPase inhibition. Calotropin, the compound with the highest degree of selectivity for BT-549 cells, increased intracellular Ca2+ in sensitive cells to a greater extent than in the resistant MDA-MB-231 cells. Further studies identified a second TNBC cell line, Hs578T, that is also highly sensitive to the cardenolides, and mechanistic studies were conducted to identify commonalities among the sensitive cell lines. Experiments showed that both cardenolide-sensitive cell lines expressed higher mRNA levels of the Na+/Ca2+ exchanger NCX1 than resistant TNBC cells. This suggests that NCX1 could be a biomarker to identify TNBC patients that might benefit from the clinical administration of a cardiac glycoside for anticancer indications.

Oleanane-type saponins and prosapogenins from Albizia julibrissin and their cytotoxic activities

Two undescribed oleanane-type saponins, julibrosides K–L, along with three undescribed oleanane-type prosapogenins, julibrosides M–O, were isolated from the stem bark of Albizia julibrissin Durazz. and the mild alkaline hydrolysate of the total saponin, r

Melanogenesis-Inhibitory and Cytotoxic Activities of Triterpene Glycoside Constituents from the Bark of Albizia procera

Five oleanane-type triterpene glycosides including three new ones, proceraosides E-G (1-3), were isolated from a MeOH-soluble extract of Albizia procera bark. The structures of 1-3 were determined by use of NMR spectra, HRESIMS, and chemical methods. Compounds 1-5 exhibited inhibitory activities against the proliferation of the A549, SKBR3, AZ521, and HL60 human cancer cell lines (IC50 0.28-1.8 μM). Additionally, the apoptosis-inducing activity of compound 2 was evaluated by Hoechst 33342 staining and flow cytometry, while the effects of 2 on the activation of caspases-9, -8, and -3 in HL60 cells were revealed by Western blot analysis.