123537-84-8

Basic information

• Product Name: (1S,2S)-1-phenyl-2-phthalimido-propane-1,3-diol
• Synonyms: (1S,2S)-1-phenyl-2-phthalimido-propane-1,3-diol
• CAS NO: 123537-84-8
• Molecular Weight: 297.31
• Mol File: 123537-84-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (1S,2S)-1-phenyl-2-phthalimido-propane-1,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-1-phenyl-2-phthalimido-propane-1,3-diol(123537-84-8)
• EPA Substance Registry System: (1S,2S)-1-phenyl-2-phthalimido-propane-1,3-diol(123537-84-8)

Safety Data

• Hazardous Substances Data: 123537-84-8(Hazardous Substances Data)

Upstream product

• 856829-95-3 N-(1-formyl-2-oxo-2-phenyl-ethyl)-phthalimide 
• 85-44-9 phthalic anhydride 
• 1884-86-2 (1S,2S)-1-(4-nitrophenyl)-2-phthalimido-1,3-propanediol 
• 119-62-0 (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol 
• 123475-38-7 (1S,2S)-1(4-aminophenyl)-2-phthalimido-propane-1,3-diol 
• 28143-91-1 (1S,2S)-2-amino-1-phenyl-1,3-diol 
• 136918-14-4 phthalimide 

Downstream Products

• 3306-06-7 (+/-)-threo-2-amino-1-phenyl-1,3-propanediol 
• 130873-80-2 (1S,2S)-1,3-dihydroxy-1-phenyl-prop-2-yl-ammonium chloride 
• 74397-35-6 (+)-(R)-2-(1-benzyl-2-iodoethyl)-1H-isoindole-1,3(2H)-dione 
• 123475-39-8 (1S,2S)-1-hydroxy-1-phenyl-2-phthalimido-3-tosyloxy-propane 
• 123475-41-2 (1S,2S)-1-phenyl-2-phthalimido-1,3-propanediol ditosyl ester 
• 158868-62-3 (1S,2S)-1,3-diiodo-1-phenyl-2-phthalimidopropane 
• 123475-40-1 (1S,2S)-1-acetoxy-1-phenyl-3-iodo-2-phthalimidopropane 
• 123537-85-9 (1S,2S)-1-acetoxy-1-phenyl-2-phthalimido-propane 
• 130926-84-0 (1R,2S)-1-chloro-3-hydroxy-1-phenyl-prop-2-yl-ammonium chloride 
• 58852-38-3 (R)-2-amino-3-phenylpropanol hydrochloride 
• 130926-85-1 (1R,2S)-2-acetamido-3-acetoxy-1-chlor-1-phenyl-propane 
• 52431-42-2 (2R)-2-acetamido-1-acetoxy-3-phenyl-propane 
• 2153-98-2 (-)-Norpseudoephedrine hydrochloride 
• 5898-99-7 (S)-N-2-phthaloylamphetamine 

Relevant articles and documents

(1S,2S)-2-Amino-1-phenyl-1,3-propanediol, a spin off from chloramphenicol manufacture, as chiral synthon for (1S, 2S)-pseudoephedrine and (R)-phenylalaninol

(1S,2S)-2-Amino-1-phenyl-1,3-propanediol (3a), a discarded optically active material in one of the processes for the manufacture of chloramphenicol, has been transformed into (S,S)-pseudoephedrine (4) and (R)-phenylalaninol (5). The opposite selectivity of highly regioselective oxidative ring opening of the benzaldehyde acetal of (1S,2S)-2-phthalimido-1-phenyl-1,3-propanediol by NBS and highly regioselective ring opening of the cyclic sulphite of the same substrate by LiBr are the key steps in the transformations respectively.

An efficient synthesis of S-(+)-amphetamine

Optically active (S)-(+)-amphetamine hydrochloride (5-HCl) was prepared from (1S,2S)-2-amino-1-phenyl-1,3-propanediol (1) via its 3-iodo intermediate (3). A phthaloyl group was used for protecting the amine function.

An efficient synthesis of (1S,2S)-1-acetoxyl-1-aryl-3-halo-2-phthalimidopropanes

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