1235457-28-9Relevant articles and documents
Titanium-mediated spirocyclization reactions of 4-alkylpyridines
Parameswarappa, Sharavathi G.,Pigge, F. Christopher
supporting information; experimental part, p. 3434 - 3437 (2010/09/08)
(Equation Presented). Pyridines substituted at the 4-position with alkyl tethers containing β-dicarbonyl moieties were converted to spirocyclic 4,4-disubstituted dihydropyridines. Optimal conditions for these transformations involved N-acylation of the pyridine substrate with a chloroformate electrophile in the presence of Ti(OiPr)4. Cyclization products could be easily converted into spiro-piperidine derivatives or elaborated into more complex heterocyclic frameworks via Au-catalyzed cycloisomerization.
