123594-06-9

Basic information

• Product Name: 5-Nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester
• Synonyms: 5-Nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester
• CAS NO: 123594-06-9
• Molecular Weight: 312.325
• Mol File: 123594-06-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester(123594-06-9)
• EPA Substance Registry System: 5-Nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester(123594-06-9)

Safety Data

• Hazardous Substances Data: 123594-06-9(Hazardous Substances Data)

Upstream product

• 41959-45-9 5-nitro-1,2,3,4-tetrahydroisoquinoline 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 123594-07-0 5-amino-3,4-dihydroisoquinoline-2(H)-carboxylic acid benzyl ester ester 
• 123594-00-3 5-Fluoro-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Affinity of 2-(tetrahydroisoquinolin-2-methyl)- and 2-(isoindolin-2-ylmethyl)imidazolines for α-adrenoceptors. Differential affinity of imidazolines for the [3H]idazoxan-labeled α2-adrenoceptor vs the [3H]yohimbine-labeled site

A series of 2-(tetrahydroisoquinolin-2-ylmethyl)- and 2-(isoindolin-2-ylmethyl)imidazolines were prepared and tested for α1- and α2-adrenoceptor affinity with radioligand binding. Several compounds, 5-fluoro- (5h), 5-chloro- (5j), 5,8-dimethoxy- (5r), and 5,8-dimethoxy-1-methyl- (5s) 2-(tetrahydroisoquinolin-2-ylmethyl)imidazoline, were found to be selective α2-adrenoceptor ligands on the basis of displacement of [3H]yohimbine from rat cerebral cortical membranes. One compound, 2-[(8-chloro tetrahydroisoquinolin-2-yl)methyl]imidazoline (5m), showed a 36-fold difference in affinity for the [3H]idazoxan-labeled α2-adrenoceptor relative to the [3H]yohimbine-labeled site, which may be evidence for α2-adrenoceptor subtypes.