1236033-34-3

Basic information

• Product Name: R-2-[[[(1,1-diMethylethyl)diMethylsilyl]oxy] diphenylMethyl]-Pyrrolidine
• Synonyms: R-2-[[[(1,1-diMethylethyl)diMethylsilyl]oxy] diphenylMethyl]-Pyrrolidine;(R)-(+)-α,α-Diphenyl-2-pyrrolidineMethanol tert-butyldiMethylsilyl ether >=97% (HPLC);(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether;(R)-2-[(tert-Butyldimethylsiloxy)diphenylmethyl]pyrrolidine;(R)-Diphenylprolinol tert-butyldimethylsilyl ether;(2R)-2-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]diphenylmethyl]pyrrolidine
• CAS NO: 1236033-34-3
• Molecular Formula: C₂₃H₃₃NOSi
• Molecular Weight: 367.59972
• Mol File: 1236033-34-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 445.2±35.0 °C(Predicted)
• Appearance: /
• Density: 0.998±0.06 g/cm3(Predicted)
• PKA: 10.12±0.10(Predicted)
• CAS DataBase Reference: R-2-[[[(1,1-diMethylethyl)diMethylsilyl]oxy] diphenylMethyl]-Pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: R-2-[[[(1,1-diMethylethyl)diMethylsilyl]oxy] diphenylMethyl]-Pyrrolidine(1236033-34-3)
• EPA Substance Registry System: R-2-[[[(1,1-diMethylethyl)diMethylsilyl]oxy] diphenylMethyl]-Pyrrolidine(1236033-34-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 1236033-34-3(Hazardous Substances Data)

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 22348-32-9 (R)-α,α-diphenylprolinol 

Relevant articles and documents

Enantioselective Construction of Spirooxindole-Fused Cyclopentanes

The present study reports an asymmetric organocatalytic cascade reaction of oxindole derivates with α,β-unsaturated aldehydes efficiently catalyzed by simple chiral secondary amine. Spirooxindole-fused cyclopentanes were produced in excellent isolated yields (up to 98%) with excellent enantiopurities (up to 99% ee) and moderate to high diastereoselectivities. The synthetic utility of the protocol was exemplified on a set of additional transformations of the corresponding spiro compounds. In addition, a study showing the promising biological activity of selected enantioenriched products was accomplished.