1236039-19-2

Basic information

• Product Name: C₁₅H₁₂ClNO₅
• Synonyms: C₁₅H₁₂ClNO₅
• CAS NO: 1236039-19-2
• Molecular Weight: 321.717
• Mol File: 1236039-19-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₂ClNO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₂ClNO₅(1236039-19-2)
• EPA Substance Registry System: C₁₅H₁₂ClNO₅(1236039-19-2)

Safety Data

• Hazardous Substances Data: 1236039-19-2(Hazardous Substances Data)

Upstream product

• 533-31-3 Sesamol 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 

Relevant articles and documents

Linking conformational flexibility and kinetics: Catalytic 1,4-type friedel-crafts reactions of phenols utilizing 1,3-diamine-tethered guanidine/bisthiourea organocatalysts

Herein, we present details of our conformationally flexible, 1,3-diamine-tethered guanidine/bisthiourea organocatalysts for chemo-, regio-, and enantioselective 1,4-type Friedel-Crafts reactions of phenols. These organocatalysts show a unique stereo-discrimination governed by the differential activation entropy (δδS+), rather than by the differential activation enthalpy (δδH+). Extensive kinetic analyses using Eyring plots for a series of guanidine/bisthiourea organocatalysts revealed the key structural motif in the catalysts associated with a large magnitude of differential activation entropy (δδS +). A plausible guanidine-thiourea cooperative mechanism for the enantioselective Friedel-Crafts reaction is proposed. Copyright