123618-00-8

Basic information

• Product Name: fedotozine
• Synonyms: fedotozine;[R,(+)]-1-Phenyl-1-[(3,4,5-trimethoxybenzyl)oxymethyl]-N,N-dimethylpropan-1-amine;JO-1196
• CAS NO: 123618-00-8
• Molecular Formula: C22H13NO4
• Molecular Weight: 0
• Mol File: 123618-00-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 453°Cat760mmHg
• Flash Point: 120.9°C
• Appearance: /
• Density: 1.061g/cm³
• Vapor Pressure: 2.14E-08mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: fedotozine(CAS DataBase Reference)
• NIST Chemistry Reference: fedotozine(123618-00-8)
• EPA Substance Registry System: fedotozine(123618-00-8)

Safety Data

• Hazardous Substances Data: 123618-00-8(Hazardous Substances Data)

Usage

Description

Fedotozine is a pharmaceutical compound that functions as a kappa (κ) opioid receptor agonist. It is characterized by its ability to selectively target and activate the kappa opioid receptors, which are involved in the modulation of pain perception and gastrointestinal motility.

Uses

Used in Pharmaceutical Industry:
Fedotozine is used as a therapeutic agent for the treatment of irritable bowel syndromes (IBS). Its action as a kappa opioid receptor agonist helps in alleviating the symptoms associated with IBS, such as abdominal pain, discomfort, and altered bowel habits. fedotozine's selective targeting of kappa receptors allows for a more focused approach to managing IBS, potentially reducing side effects commonly associated with broader opioid receptor agonists.
Additionally, fedotozine is recognized for its potential as a visceral analgesic. This application is based on its ability to modulate pain perception in the gastrointestinal tract, providing relief from pain and discomfort associated with various gastrointestinal disorders. The selective activation of kappa opioid receptors by fedotozine may offer a more targeted and effective approach to managing visceral pain, with fewer side effects compared to traditional analgesics.

InChI:InChI=1/C22H31NO4/c1-7-22(23(2)3,18-11-9-8-10-12-18)16-27-15-17-13-19(24-4)21(26-6)20(14-17)25-5/h8-14H,7,15-16H2,1-6H3/t22-/m0/s1

Upstream product

• 123-91-1 1,4-dioxane 
• 39068-94-5 2-phenyl-2-dimethylamino-1-butanol 

Related news

The κ agonist fedotozine (cas 123618-00-8) modulates colonic distention-induced inhibition of gastric motility and emptying in dogs08/11/2019

Background/Aims: Gastric motor disturbances, associated with a delay in gastric emptying, occur in patients with the irritable bowel syndrome. The influence of fedotozine and κ agonists on the cologastric reflex produced by nonpainful colonic distention was evaluated in conscious dogs. Methods:...detailed

fedotozine (cas 123618-00-8) reverses ileus induced by surgery or peritonitis: Action at peripheral Κ-Opioid receptors08/10/2019

Background: Fedotozine is a peripheral opioid agonist. Its effects were assessed in experimental ileus in rats. Methods: Ileus was induced by abdominal surgery (laparotomy and cecum palpation) or peritonitis (acetic acid, intraperitoneally). Digestive motility was recorded by electromyography an...detailed

Effect of fedotozine (cas 123618-00-8) on the cardiovascular pain reflex induced by distension of the irritated colon in the anesthetized rat08/09/2019

The effect of fedotozine was evaluated in a model of colonic hypersensibility to balloon distension in anesthetized rats. Acetic acid (0.6%, intracolonically) significantly enhanced the hypotension reflex response to colonic distension (Pdetailed

The κ agonist fedotozine (cas 123618-00-8) relieves hypersensitivity to colonic distention in patients with irritable bowel syndrome08/08/2019

Background & Aims: Visceral hypersensitivity plays a major role in the pathophysiology of inflammatory bowel syndrome (IBS). Opioid κ receptors on afferent nerves may modulate it and may be the target of new IBS treatments. The aim of this study was to evaluate the effects of fedotozine, a pote...detailed

fedotozine (cas 123618-00-8) blocks hypersensitive visceral pain in conscious rats: action at peripheral κ-opioid receptors08/07/2019

The effect of fedotozine on visceral hypersensitivity was evaluated in conscious rats. One hour after colonic irritation (0.6% acetic acid intracolonically), a 30 mmHg colonic distension was applied for 10 min. Irritation increased the number of abdominal contractions induced by colonic distensi...detailed

Relevant articles and documents

(+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-N-propylamine, process for preparing it and its therapeutical use

(+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylamine of formula STR1 is a medicament of use in gastroenterology.