1236202-53-1

Basic information

• Product Name: C₂₆H₁₉ClF₃N₅O
• CAS NO: 1236202-53-1
• Molecular Weight: 509.918
• Mol File: 1236202-53-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₁₉ClF₃N₅O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₁₉ClF₃N₅O(1236202-53-1)
• EPA Substance Registry System: C₂₆H₁₉ClF₃N₅O(1236202-53-1)

Safety Data

• Hazardous Substances Data: 1236202-53-1(Hazardous Substances Data)

Upstream product

• 53985-49-2 3-chloro-5-(trifluoromethyl)benzoic acid 
• 1236202-82-6 C₁₈H₁₇N₅ 

Relevant articles and documents

1,4-Dihydropyrazolo[4,3-d]imidazole phenyl derivatives: A novel type II Raf kinase inhibitors

The synthesis of a novel series of 1,4-dihydropyrazolo[4,3-d]imidazole phenyl derivatives 1a-b, 2a-v and their antiproliferative activities against A375P and WM3629 human melanoma cell line were described. Most compounds showed competitive antiproliferative activities to sorafenib, the reference standard. Among them, pyrazoloimidazole phenyl urea compounds 2a, 2d, 2g, 2i, 2t exhibited potent activities on WM3629 cell lines (IC50 = 0.56-0.86 μM). Especially, 2t was found to be a potent and selective C-Raf inhibitor, showing a possibility as melanoma therapeutics.