1236273-03-2

Basic information

• Product Name: C₁₁H₂₂N₂O₂
• CAS NO: 1236273-03-2
• Molecular Weight: 214.308
• Mol File: 1236273-03-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₁H₂₂N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₂₂N₂O₂(1236273-03-2)
• EPA Substance Registry System: C₁₁H₂₂N₂O₂(1236273-03-2)

Safety Data

• Hazardous Substances Data: 1236273-03-2(Hazardous Substances Data)

Upstream product

• 53788-49-1 tert-butyl 4-methylpiperazine-1-carboxylate 
• 74-88-4 methyl iodide 

Relevant articles and documents

Dynamic thermodynamic resolution of lithiated N-Boc-N′- alkylpiperazines

Deprotonation of N-Boc-N′-alkylpiperazines with sec-BuLi in Et 2O-TMEDA gave the 2-lithio derivatives which were resolved in the presence of a chiral ligand. The best ligands for the asymmetric substitution were diamino-alkoxides that promoted a dynamic thermodynamic resolution (DTR) of the organolithium at -30 °C. Electrophilic quench gave enantiomerically enriched 2-substituted piperazines. Of a selection of piperazines, the N′-t-butyl derivative gave the best results, with the product N-Boc-N′-t-butyl-2-substituted piperazines being formed with enantiomer ratios up to 81:19.