1236277-63-6

Basic information

• Product Name: 2-(2,6-difluorophenyl)pyrimidine-4-carboxylic acid
• Synonyms: 2-(2,6-difluorophenyl)pyrimidine-4-carboxylic acid
• CAS NO: 1236277-63-6
• Molecular Weight: 236.178
• Mol File: 1236277-63-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(2,6-difluorophenyl)pyrimidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-difluorophenyl)pyrimidine-4-carboxylic acid(1236277-63-6)
• EPA Substance Registry System: 2-(2,6-difluorophenyl)pyrimidine-4-carboxylic acid(1236277-63-6)

Safety Data

• Hazardous Substances Data: 1236277-63-6(Hazardous Substances Data)

Upstream product

• 149849-92-3 2‐chloropyrimidine‐4‐carboxylic acid 
• 162101-25-9 2,6-difluorophenylboronic acid 

Relevant articles and documents

Oxazolyl pyrimidinone amide compound or medicinal salt thereof, preparation method and application of oxazolyl pyrimidinone amide compound or medicinal salt thereof

The invention discloses an oxazole pyrimidone amide compound or a pharmaceutically acceptable salt thereof, and a preparation method and application thereof. The oxazole pyrimidone amide compound has the following structural general formula (I) shown in the description, wherein R1 and R2 are respectively and independently selected from hydrogen and C1-3 alkyl, R3 is selected from C1-3 alkyl groups, R4 and R5 are independently selected from 5-6-membered aryl groups, the aryl groups are phenyl groups or heteroaryl groups containing 1-3 heteroatoms, the heteroatoms are selected from oxygen atoms or nitrogen atoms, and the heteroatoms are located at any position on the heteroaryl groups; the aryl is unsubstituted or at least substituted by one or more halogens or C1-3 alkyl groups, C1-3 polyhalogenated alkyl groups and C1-3 alkoxy groups. The invention also discloses an application of the compound as a TRPA1 antagonist, and the compound is used for preparing medicines for treating or preventing diseases, symptoms and/or obstacles regulated by TRPA1, such as pain and the like.

BENZIMIDAZOLE AND INDOLE COMPOUNDS AND USES THEREOF

Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associate

NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS

The present invention provides a compound of formula (A): I as described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by PIM kinase using the compounds of Formula I, and pharmaceutical compositions comprising such compounds.