1236301-32-8Relevant articles and documents
Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors
Nishii, Hiroki,Chiba, Takashi,Morikami, Kenji,Fukami, Takaaki A.,Sakamoto, Hiroshi,Ko, Kwangseok,Koyano, Hiroshi
, p. 1405 - 1409 (2010)
A novel quinoline derivative that selectively inhibits c-Met kinase was identified. The molecular design is based on a result of the analysis of a PF-2341066 (1)/c-Met cocrystal structure (PDB code: 2wgj). The kinase selectivity of the derivatives is discussed from the view point of the sequence homology of the kinases, the key interactions found in X-ray cocrystal structures, and the structure-activity relationship (SAR) obtained in this work.
