1236458-26-6Relevant articles and documents
Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2′-C-methyl-6-O-methyl guanosine nucleoside and l-Alanine ester phosphoramidates
Bourdin, Claire,McGuigan, Christopher,Brancale, Andrea,Chamberlain, Stanley,Vernachio, John,Hutchins, Jeff,Gorovits, Elena,Kolykhalov, Alexander,Muhammad, Jerry,Patti, Joseph,Henson, Geoffrey,Bleiman, Blair,Bryant, K. Dawn,Ganguly, Babita,Hunley, Damound,Obikhod, Aleksandr,Walters, C. Robin,Wang, Jin,Ramamurty, Changalvala V.S.,Battina, Srinivas K.,Srivinas Rao
, p. 2260 - 2264 (2013)
7-Deazapurines are known to possess broad antiviral activity, however the 2′-C-methylguanosine analogue displays poor cell permeation and limited phosphorylation, thus is not an efficient inhibitor of hepatitis C virus (HCV) replication. We previously rep