1236876-59-7

Basic information

• Product Name: 1-nitroxyacetic acid 2-methoxy-4-[(8-methylnonanoylamino)methyl]phenyl ester
• CAS NO: 1236876-59-7
• Molecular Weight: 410.467
• Mol File: 1236876-59-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-nitroxyacetic acid 2-methoxy-4-[(8-methylnonanoylamino)methyl]phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-nitroxyacetic acid 2-methoxy-4-[(8-methylnonanoylamino)methyl]phenyl ester(1236876-59-7)
• EPA Substance Registry System: 1-nitroxyacetic acid 2-methoxy-4-[(8-methylnonanoylamino)methyl]phenyl ester(1236876-59-7)

Safety Data

• Hazardous Substances Data: 1236876-59-7(Hazardous Substances Data)

Upstream product

• 19408-84-5 dihydrocapsaicin 

Relevant articles and documents

Synthesis and biological evaluation of nitric oxide-releasing derivatives of capsaicin as analgesia drugs

TRPV1 is a ligand-gated non-selective cation channel that is considered to be an important pain integrator. Capsaicin, the prototypical TRPV1 agonist, has a clear therapeutic potential. In this letter, for lowering its pungency, a series of nitric oxide-releasing derivatives of capsaicin were designed and synthesized, including 10 compounds which were the direct combination of capsaicin and dihydro capsaicin with various nitric oxide donors. Preliminary biological tests suggested the compounds had both TRPV1 agonist activity and nitric oxide release activity. Compound B2, B5, B8 had better analgesic activity than capsaicin. Based on these results, Compound B2, B5, B8 can be considered as lead candidates for the further development of analgesic drugs.