123743-71-5Relevant articles and documents
Mechanisms of Reductive Methylation of NAD+ Analogues by a trans-Dimethylcobalt(III) Complex
Fukuzumi, Shunichi,Kitano, Toshiaki
, p. 41 - 45 (2007/10/02)
Various NAD+ analogues are readily reduced by a trans-dimethylcobalt(III) complex, trans- (L = 11-hydroxy-2,3,9,10-tetramethyl-1,4,8,11-tetraazaundeca-1,3,8,10-tetraene-1-olate), to yield the corresponding methylated NADH analogues, while cis-dialkyl- or monoalkylcobalt(III) complexes show no reactivity towards NAD+ analogues.The charge distribution of NAD+ analogues, as well as the thermodynamic stability of the products, is shown to be an important factor in determining the isomer distribution of the methylated products.The observed second-orderrate constants for the reduction of NAD+ analogues by trans- in acetonitrile at 298 K are much larger than those estimated for outer-sphere electron transfer from trans- to NAD+ analogues.