123751-61-1Relevant articles and documents
Synthesis and Antifolate Properties of 10-Alkyl-5,10-dideaza Analogues of Methotrexate and Tetrahydrofolic Acid
DeGraw, Joseph I.,Christie, Pamela H.,Kisliuk, Roy L.,Gaumont, Yvette,Sirotnak, Francis M.
, p. 673 - 677 (1990)
Synthesis of the 10-methyl and 10-ethyl analogues of 5,10-dideazatetrahydrofolic acid (DDTHF), a potent inhibitor of glycinamide ribotide (GAR) formyltransferase, is reported.Key intermediates in the process were 10-methyl- and 10-ethyl-4-amino-4-deoxy-5,