Cas 1237750-52-5,3-(4-methyl-1H-imidazol-1-yl)-N-(4-methyl-3-(1-methyl-7-(methylthio)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-5-(trifluoromethyl)benzamide

1237750-52-5

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Product Name: 3-(4-methyl-1H-imidazol-1-yl)-N-(4-methyl-3-(1-methyl-7-(methylthio)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-5-(trifluoromethyl)benzamide
Synonyms: 3-(4-methyl-1H-imidazol-1-yl)-N-(4-methyl-3-(1-methyl-7-(methylthio)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-5-(trifluoromethyl)benzamide
CAS NO:1237750-52-5
Molecular Formula:
Molecular Weight: 567.594
EINECS: N/A
Product Categories: N/A
Mol File: 1237750-52-5.mol
Article Data: 1

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
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Density: N/A
Refractive Index: N/A
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Solubility: N/A
CAS DataBase Reference: 3-(4-methyl-1H-imidazol-1-yl)-N-(4-methyl-3-(1-methyl-7-(methylthio)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-5-(trifluoromethyl)benzamide(CAS DataBase Reference)
NIST Chemistry Reference: 3-(4-methyl-1H-imidazol-1-yl)-N-(4-methyl-3-(1-methyl-7-(methylthio)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-5-(trifluoromethyl)benzamide(1237750-52-5)
EPA Substance Registry System: 3-(4-methyl-1H-imidazol-1-yl)-N-(4-methyl-3-(1-methyl-7-(methylthio)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-5-(trifluoromethyl)benzamide(1237750-52-5)

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Safety Statements: N/A
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HazardClass: N/A
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Hazardous Substances Data: 1237750-52-5(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1237750-52-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,7,7,5 and 0 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1237750-52:
(9*1)+(8*2)+(7*3)+(6*7)+(5*7)+(4*5)+(3*0)+(2*5)+(1*2)=155
155 % 10 = 5
So 1237750-52-5 is a valid CAS Registry Number.

1237750-52-5Upstream product

1237750-52-5Downstream Products

1237750-53-6 3-(4-methyl-1H-imidazol-1-yl)-N-(4-methyl-3-(1-methyl-7-(methylsulfonyl)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-5-(trifluoromethyl)benzamide

1237750-52-5Relevant articles and documents

A type-ii kinase inhibitor capable of inhibiting the T315I "Gatekeeper" mutant of Bcr-Abl

Choi, Hwan Geun,Ren, Pingda,Adrian, Francisco,Sun, Fangxian,Lee, Hyun Soo,Wang, Xia,Ding, Qiang,Zhang, Guobao,Xie, Yongping,Zhang, Jianming,Liu, Yi,Tuntland, Tove,Warmuth, Markus,Manley, Paul W.,Mestan, Jürgen,Gray, Nathanael S.,Sim, Taebo

experimental part, p. 5439 - 5448 (2010/11/05)

The second generation of Bcr-Abl inhibitors nilotinib, dasatinib, and bosutinib developed to override imatinib resistance are not active against the T315I "gatekeeper" mutation. Here we describe a type-II T315I inhibitor 2 (GNF-7), based upon a 3,4-dihydr

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