123858-53-7Relevant articles and documents
Polycyclic Aromatic Alkaloids, V. - Synthesis of 2-Bromoleptoclinidinone
Bracher, Franz
, p. 205 - 206 (2007/10/02)
4-Bromo-2-nitroacetophenone (6) is selectively reduced to the amine 7 by Fe in aqueous acetic acid.Oxidative amination of quinolinequinone 8 with 7 gives 9.Acid-catalysed cyclization of 9, followed by anellation of a pyridine ring, gives the cytotoxic pentacyclic alkaloid 2-bromoleptoclinidinone (3).