1239233-87-4 Usage
Description
2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid is a chemical compound that serves as an impurity in Febuxostat (F229000), a medication used for the treatment of hyperuricemia and chronic gout. 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid features a thiazolecarboxylic acid structure with a carboxyphenyl and methylpropoxyphenyl group attached, contributing to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid is used as an impurity in Febuxostat for the treatment of hyperuricemia and chronic gout. It is important to monitor and control the presence of this impurity in the manufacturing process to ensure the safety and efficacy of the medication.
As an impurity in Febuxostat, this compound is relevant to the pharmaceutical industry for quality control and assurance purposes. The presence of impurities can affect the potency, safety, and overall performance of a drug, so it is crucial to understand and manage their impact on the final product.
Check Digit Verification of cas no
The CAS Registry Mumber 1239233-87-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,9,2,3 and 3 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1239233-87:
(9*1)+(8*2)+(7*3)+(6*9)+(5*2)+(4*3)+(3*3)+(2*8)+(1*7)=154
154 % 10 = 4
So 1239233-87-4 is a valid CAS Registry Number.
1239233-87-4Relevant articles and documents
TREATMENT ACTIVITY AND NURSING VALUES OF A HETEROCYCLIC COMPOUND COMBINED WITH ASPIRIN ON TRAUMATIC ARTHRITIS
Li, Y.,Wang, L.,Xu, J.,Yang, H.,Zhao, X.
, p. 1563 - 1568 (2021/11/20)
Abstract: Heterocyclic compound 2-(3-(ethoxycarbonyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid (1) designed using 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid (2, Febuxostat) as a starting material is successfully prepared via a multistage synthesis route and finally characterized by IR,1H NMR, and single crystal X-ray diffraction. Its treatment activity combined with aspirin on traumatic arthritis is evaluated along with the related mechanism. Firstly, the ELISA detection is conducted to determine the inflammatory response released into the joint cavity secretion. Additionally, real time RT-PCR is measured and the activation levels of NF-κb are determined after the indicated treatment. [Figure not available: see fulltext.]
