123942-12-1

Basic information

• Product Name: ethyl 3-(4-bromo-2,5-difluorophenyl)-3-oxopropanoate
• Synonyms: ethyl 3-(4-bromo-2,5-difluorophenyl)-3-oxopropanoate
• CAS NO: 123942-12-1
• Molecular Weight: 307.091
• Mol File: 123942-12-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 3-(4-bromo-2,5-difluorophenyl)-3-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(4-bromo-2,5-difluorophenyl)-3-oxopropanoate(123942-12-1)
• EPA Substance Registry System: ethyl 3-(4-bromo-2,5-difluorophenyl)-3-oxopropanoate(123942-12-1)

Safety Data

• Hazardous Substances Data: 123942-12-1(Hazardous Substances Data)

Upstream product

• 28314-82-1 4-bromo-2,5-difluorobenzoic acid 
• 6148-64-7 ethyl potassium malonate 
• 399-94-0 2-bromo-1,4-difluorobenzene 
• 123942-11-0 4'-bromo-2 ',5'-difluoroacetophenone 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 1429511-15-8 ethyl 5-[2,5-difluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylate 
• 1429511-16-9 5-[2,5-difluoro-4-(2-methoxy-4,6-dimethyl-pyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylic acid 
• 1429511-17-0 5-[2,5-difluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide 
• 1429511-18-1 ethyl 5-(2,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-((S)-tetrahydrofuran-3-yl)-1H-pyrazole-4-carboxylate 
• 1429511-20-5 5-(2,5-difluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxamide 
• 1429511-21-6 ethyl 5-(2,5-difluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate 
• 1429511-22-7 5-(2,5-difluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxamide 
• 1429511-19-2 ethyl 5-(2,5-difluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate 
• 1449785-65-2 5-(2,5-difluoro-4-(2-methoxy-3,5-dimethylpyridin-4-yl)phenyl)-1-((S)-tetrahydrofuran-3-yl)-1H-pyrazole-4-carboxylic acid 
• 1429511-23-8 ethyl 5-(2,5-difluoro-4-(6-methoxy-2,4-dimethylpyridin-3-yl)phenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate 
• 1449784-96-6 5-(2,5-difluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylic acid 
• 1429510-42-8 ethyl 5-(4-bromo-2,5-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylate 
• 1429510-43-9 ethyl 5-(4-bromo-2,5-difluorophenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate 
• 167556-68-5 7-(2,6-Dimethyl-pyridin-4-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 

Relevant articles and documents

PYRAZOLOQUINOLINE DERIVATIVES

A compound and/or pharmacologically acceptable salt thereof represented by the formula (I) has PDE9 inhibitory action, so that the intracerebral cGMP concentration is anticipated to be elevated. The PDE9 inhibitory action and the increase in cGMP lead to the improvement of learning and memory behaviors, and the compound (I) has applicability as a therapeutic agent for cognitive dysfunctions in Alzheimer's disease. wherein R1 is a hydrogen atom; R2 is an aromatic ring group, etc.; R3 is a hydrogen atom, etc; R4 is a hydrogen atom; R5 is an oxepanyl group, etc.; R6 is a hydrogen atom.

ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS

The invention provides compounds and salts of Formula (I) and Formula (II): which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula (I) and Formula (II). The variables A1, R2, R3, R5, R6, R7, A8 and R9 are defined herein. Certain compounds of Formula (I) and Formula (II) disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula (I) or Formula (II) and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula (I) or Formula (II) as the only active agent or may contain a combination of a compound of Formula (I) or Formula (II) and one or more other active agents. The invention also provides methods for treating microbial infections in animals.