123949-01-9 Usage
Uses
Used in Pharmaceutical Industry:
The compound's application in the pharmaceutical industry is primarily due to its potential in the development of novel cancer treatments. By inhibiting topoisomerase I, these analogs can disrupt DNA replication, leading to the prevention of tumor growth and the potential eradication of cancer cells. This makes (4S)-10-(EthoxyMethyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione a valuable asset in the fight against cancer and a promising candidate for further research and development in the pharmaceutical sector.
Check Digit Verification of cas no
The CAS Registry Mumber 123949-01-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,9,4 and 9 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 123949-01:
(8*1)+(7*2)+(6*3)+(5*9)+(4*4)+(3*9)+(2*0)+(1*1)=129
129 % 10 = 9
So 123949-01-9 is a valid CAS Registry Number.
123949-01-9Relevant articles and documents
The solvolysis of topotecan in alcohols and acetic anhydride
Li, Jiajun,Wang, Guolin,Dong, Mengjie,Zhang, Qian
scheme or table, p. 2324 - 2326 (2011/06/17)
Six derivatives of 10-hydroxycamptothecin were prepared via solvolysis of topotecan in corresponding alcohols and acetic anhydride. We attributed the specific reactivity of topotecan to the internal hydrogen-bonding between 10-hydroxy and the nitrogen atom in position 9. As a result the reaction underwent through an intermediate ortho-quionomethlide species to reach equilibrium. Bioactivity screening data showed all products could potentially inhibit the proliferation of several cancer cell lines in vitro and a bigger size group in 9-position would be favorable for the anti-tumor activities observably.
