1239513-15-5Relevant articles and documents
ZrCl4 catalyzed efficient one-pot synthesis of novel methylene-bis-β-amino/methylene-bi.-β-acetamido ketones
Reddy, Ch. Sanjeeva,Nagaraj,Srinivas,Reddy, G. Purnachandra
experimental part, p. 617 - 622 (2010/12/18)
Zirconium(IV)chloride (ZrCl4) catalyzed efficient one-pot synthesis of methylene-bis-β-amino/methylene-bis-β-acetamido ketones at room temperature has been described. In the presence of ZrCl4, the three-component Mannich-type reaction via a variety of in situ generated aldimines with various ketones, methylenebis-methoxybenzaldehyde and aromatic amines in ethanol, led to the formation of mefhylene-bis-β-amino ketones and the fourcomponent Mannich-type reaction of mefhylene-bis-methoxybenzaldehyde with ketones, acetonitrile and acetyl chloride resulted in the corresponding methylene-bis-β-acetamido ketones in high to excellent yields. All the newly synthesized compounds have been characterized by their spectral and elemental analyses.
