1239719-55-1

Basic information

• Product Name: 4-bromo-2-(4-fluorophenyl)-1-methyl-1H-benzimidazole
• Synonyms: 4-bromo-2-(4-fluorophenyl)-1-methyl-1H-benzimidazole
• CAS NO: 1239719-55-1
• Molecular Weight: 305.149
• Mol File: 1239719-55-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-bromo-2-(4-fluorophenyl)-1-methyl-1H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2-(4-fluorophenyl)-1-methyl-1H-benzimidazole(1239719-55-1)
• EPA Substance Registry System: 4-bromo-2-(4-fluorophenyl)-1-methyl-1H-benzimidazole(1239719-55-1)

Safety Data

• Hazardous Substances Data: 1239719-55-1(Hazardous Substances Data)

Upstream product

• 1150617-53-0 3-bromo-N-methyl-2-nitrobenzenamine 
• 1150617-55-2 3-bromo-N¹-methylbenzene-1,2-diamine 
• 886762-70-5 2?bromo?6?fluoronitrobenzene 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 1239717-50-0 C₂₅H₂₂FN₅O 
• 1239717-44-2 C₂₅H₂₂FN₅O 
• 1239717-45-3 C₂₃H₁₈FN₅O 
• 1216292-61-3 2-(4-fluorophenyl)-1-methyl-1H-benzimidazol-4-ylamine 
• 1240608-96-1 [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[4-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine 
• 1240608-97-2 [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[5-methoxy-6-(4-methylimidazol-1-yl)pyridin-3-yl]amine 
• 1240608-28-9 [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[6-(4-methylimidazol-1-yl)pyridin-3-yl]amine 
• 1240608-27-8 [3-fluoro-4-(4-methylimidazol-1-yl)phenyl]-[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]amine 
• 1240608-99-4 [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[6-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine 
• 1240608-83-6 [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[5-(4-methylimidazol-1-yl)pyridin-2-yl]amine 
• 1240609-22-6 2-(4-fluorophenyl)-1-methyl-N-[2-(4-methyl-1H-imidazol-1-yl)-5-pyrimidinyl]-1H-benzimidazol-4-amine 
• 1240608-32-5 2-(4-fluorophenyl)-N-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-1-methyl-1H-benzimidazol-4-amine 
• 1240608-23-4 2-(4-fluorophenyl)-1-methyl-N-[4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-benzimidazol-4-amine 

Relevant articles and documents

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators

The design and the synthesis of several chemical subclasses of imidazole containing γ-secretase modulators (GSMs) is described. Conformational restriction of pyridone 4 into bicyclic pyridone isosteres has led to compounds with high in vitro and in vivo p

NOVEL SUBSTITUTED BENZOXAZOLE, BENZIMIDAZOLE, OXAZOLOPYRIDINE AND IMIDAZOPYRIDINE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives of Formula (I) wherein R1, R2, R3, R4, X, A1, A2, A3, A4, Y1, Y2, Y3 and Z have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.