123975-52-0

Basic information

• Product Name: t-butyl 2-benzyloxycarbonylamino-3-carbomethoxy-4-phenyl-(2S)-butanoate
• CAS NO: 123975-52-0
• Molecular Weight: 427.497
• Mol File: 123975-52-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: t-butyl 2-benzyloxycarbonylamino-3-carbomethoxy-4-phenyl-(2S)-butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: t-butyl 2-benzyloxycarbonylamino-3-carbomethoxy-4-phenyl-(2S)-butanoate(123975-52-0)
• EPA Substance Registry System: t-butyl 2-benzyloxycarbonylamino-3-carbomethoxy-4-phenyl-(2S)-butanoate(123975-52-0)

Safety Data

• Hazardous Substances Data: 123975-52-0(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 3160-47-2 N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester 
• 4276-08-8 β-methyl N-benzyloxycarbonyl-DL-aspartate 
• 47307-26-6 (S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester 
• 60079-12-1 β-Methyl α-tert-butyl (2S)-N-(benzyloxycarbonyl)aspartate 
• 100-39-0 benzyl bromide 
• 127605-37-2 α-t-butyl β-methyl N-Z-(RS)-aspartate 

Downstream Products

• 133637-88-4 2-{1-Benzyl-2-[(E)-cyanoimino]-5-oxo-imidazolidin-4-yl}-3-phenyl-propionic acid methyl ester 
• 133637-93-1 (4S,5S)-1,5-Dibenzyl-2-[(E)-cyanoimino]-6-oxo-hexahydro-pyrimidine-4-carboxylic acid tert-butyl ester 
• 133637-86-2 C₂₄H₂₇N₃O₅ 
• 133637-87-3 (4S,5R)-1,5-Dibenzyl-2-[(E)-cyanoimino]-6-oxo-hexahydro-pyrimidine-4-carboxylic acid tert-butyl ester 
• 133637-86-2 C₂₄H₂₇N₃O₅ 
• 60425-49-2 (+)-α-amino-4-phenylbutyric acid methyl ester hydrochloride 
• 127605-44-1 (S)-homophenylalanine hydrobromide 
• 127605-53-2 t-butyl N-Z-(S)-homophenylalanine 
• 123975-65-5 t-butyl N-(2-methoxy-2-phenyl-3,3,3-trifluoro-(R)-propionoyl)-2-amino-3-carbomethoxy-4-phenyl-(2S)-butanoate 
• 123975-65-5 t-butyl N-(2-methoxy-2-phenyl-3,3,3-trifluoro-(R)-propionoyl)-2-amino-3-carbomethoxy-4-phenyl-(2RS)-butanoate 
• 127605-48-5 t-butyl 2-amino-3-carbomethoxy-4-phenyl-(2S)-butanoate 
• 144787-22-4 t-butyl 2-benzyloxycarbonylamino-3-carboxy-4-phenyl-(2S)-butanoate 
• 127605-48-5 t-butyl 2-amino-3-carbomethoxy-4-phenyl-(2RS)-butanoate 

Relevant articles and documents

Non-Proteinogenic Amino Acid Synthesis. The β-Anion Derived from Aspartic Acid, and its Application to α-Amino Acid Synthesis.

Treatment of α-t-butyl β-methyl N-Z-(S)-aspartate (2) with lithium amide bases generates the corresponding β-ester enolate, which can be alkylated with suitable electrophiles.The application of this strategy for synthesis of optically active amino acids h

Asymmetric Amino Acid Synthesis: Preparation of the β Anion derived from Aspartic Acid

(S)-1-t-Butyl 4-methyl N-benzyloxycarbonylaspartate (5a), and (S)-1-t-butyl 4-allyl N-benzyloxycarbonylaspartate (5b) have been synthesized from (S)-aspartic acid (2), and can be readily alkylated and hydroxyalkylated at the β-carbon for asymmetric amino acid synthesis.