123979-03-3Relevant articles and documents
An in vivo active 1,2,5-oxadiazole Pt(II) complex: A promising anticancer agent endowed with STAT3 inhibitory properties
Porta, Federica,Facchetti, Giorgio,Ferri, Nicola,Gelain, Arianna,Meneghetti, Fiorella,Villa, Stefania,Barlocco, Daniela,Masciocchi, Daniela,Asai, Akira,Miyoshi, Nao,Marchianò, Silvia,Kwon, Byoung-Mog,Jin, Yena,Gandin, Valentina,Marzano, Cristina,Rimoldi, Isabella
, p. 196 - 206 (2017)
New Pt(II) complexes (Pt-1-3) bearing 1,2,5-oxadiazole ligands (1-3) were synthesized, characterized and evaluated for their ability to disrupt STAT3 dimerization. Ligand 3·HCl showed cytotoxic effects on HCT-116 cells (IC50 = 95.2 μM) and a se