123994-80-9 Usage
Chemical compound
2-[(3,4-difluorophenyl)amino]-3,7-dihydro-6H-purin-6-one
Class
Purine analogues
Mechanism of action
Non-nucleoside inhibitor of the viral RNA-dependent RNA polymerase
Potential use
Treatment for hepatitis C
Mode of action
Interferes with replication of hepatitis C virus
Suitability
Promising candidate for combination therapies for hepatitis C
Clinical trials
Subject of several trials with efficacy in reducing viral load
Approval status
Not yet approved for commercial use
Promise
Potential treatment option for hepatitis C infection
Check Digit Verification of cas no
The CAS Registry Mumber 123994-80-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,9,9 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 123994-80:
(8*1)+(7*2)+(6*3)+(5*9)+(4*9)+(3*4)+(2*8)+(1*0)=149
149 % 10 = 9
So 123994-80-9 is a valid CAS Registry Number.
123994-80-9Relevant articles and documents
Structure-Activity Relationships of N2-Substituted Guanines as Inhibitors of HSV1 and HSV2 Thymidine Kinases
Hildebrand, Catherine,Sandoli, Daniele,Focher, Federico,Gambino, Joseph,Ciarrocchi, Giovanni,et al.
, p. 203 - 206 (2007/10/02)
A series of N2-phenylguanines was synthesized and tested for inhibition of the thymidine kinases encoded by Herpes simplex viruses type 1 and type 2.Compounds with hydrophobic, electron-attracting groups in the meta position of the phenyl ring
