124010-10-2

Basic information

• Product Name: 3-Carbethoxy-4-(4-chloro-2,5-dimethoxyphenyl)-3-butenoic acid
• Synonyms: 3-Carbethoxy-4-(4-chloro-2,5-dimethoxyphenyl)-3-butenoic acid
• CAS NO: 124010-10-2
• Molecular Weight: 328.749
• Mol File: 124010-10-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-Carbethoxy-4-(4-chloro-2,5-dimethoxyphenyl)-3-butenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Carbethoxy-4-(4-chloro-2,5-dimethoxyphenyl)-3-butenoic acid(124010-10-2)
• EPA Substance Registry System: 3-Carbethoxy-4-(4-chloro-2,5-dimethoxyphenyl)-3-butenoic acid(124010-10-2)

Safety Data

• Hazardous Substances Data: 124010-10-2(Hazardous Substances Data)

Upstream product

• 90064-48-5 4-chloro-2,5-dimethoxybenzaldehyde 
• 123-25-1 succinic acid diethyl ester 
• 2675-78-7 2-Chloro-5-methyl-1,4-dimethoxybenzene 
• 24599-58-4 2,5-dimethoxy toluene 
• 95-71-6 2-methylbenzene-1,4-diol 
• 124010-13-5 1-(bromomethyl)-4-chloro-2,5-dimethoxybenzene 
• 2100-42-7 2-chloro-1,4-dimethoxybenzene 

Downstream Products

• 124010-11-3 Ethyl 4-(acetyloxy)-6-chloro-5,8-dimethoxy-2-naphthalenecarboxylate 
• 25186-77-0 4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid 
• 569-05-1 1,8-dihydroxy-3-hydroxymethyl-6-methoxy-anthraquinone 
• 481-73-2 citreorosein 

Relevant articles and documents

Preparation of Functionalized Juglone Acetates and Juglones via 1,4-Dimethoxynaphthalene Derivatives: Synthesis of Anthraquinones Related to Rhein and Aloe Emodin

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Synthesis of pluraflavin A "aglycone"

The "aglycone" of pluraflavin A (2) has been synthesized. The key features of this synthesis include a 1,3-dipolar cycloaddition between a nitrile oxide (cf. 14) and an olefin (22) to yield an isoxazoline followed by subsequent conversion into the γ-pyrone of pluraflavin A. The epoxide moiety linked to the pyrone is installed prior to Diels-Alder installation of the D ring, which allows access to a number of potentially active cytotoxic intermediates en route to the final compound. The preliminary in vitro results of two such compounds are also included with the racemic title compound exhibiting cytotoxicity in the nanomolar range.