1240167-86-5

Basic information

• Product Name: 2,3-bis(4-methoxyphenyl)-6-nitroimidazo[2,1-b][1,3]benzothiazole
• Synonyms: 2,3-bis(4-methoxyphenyl)-6-nitroimidazo[2,1-b][1,3]benzothiazole
• CAS NO: 1240167-86-5
• Molecular Weight: 431.472
• Mol File: 1240167-86-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,3-bis(4-methoxyphenyl)-6-nitroimidazo[2,1-b][1,3]benzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-bis(4-methoxyphenyl)-6-nitroimidazo[2,1-b][1,3]benzothiazole(1240167-86-5)
• EPA Substance Registry System: 2,3-bis(4-methoxyphenyl)-6-nitroimidazo[2,1-b][1,3]benzothiazole(1240167-86-5)

Safety Data

• Hazardous Substances Data: 1240167-86-5(Hazardous Substances Data)

Upstream product

• 99-09-2 3-nitro-aniline 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 27895-95-0 2-bromo-1,2-bis(4-methoxyphenyl)ethanone 
• 73458-39-6 5-nitro-benzothiazol-2-ylamine 

Relevant articles and documents

Synthesis and preliminary in-vitro cytotoxic activity of novel substituted diaryl-imidazo [2, 1, b]-benzothiazole derivatives

A novel series of substituted diaryl imidazo[2, 1-b]benzothiazole derivatives (8a-y) were synthesized by condensation reaction between 2-amino benzothiazole derivatives (3a-g) and substituted a-bromo-1, 2-(substituted) diaryl-1-ethanones (7a-i). The structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopical data. The compounds (8a-y) were evaluated for their in-vitro cytotoxic activity on murine (B16F10) and human (MCF-7) cancer cells by using MTT assay. From the in vitro studies compounds 8p, 8u and 8y were found most effective with an IC50 range of 0.56-27.50 μM in MCF-7 and 2.57-36.54 μM in B16F10 cells.

Synthesis and antibacterial activity of a novel series of 2,3-diaryl-substituted-imidazo(2,1-b)-benzothiazole derivatives

Benzothiazole and imidazole compounds are extensively studied heterocyclics due to their wide spectrum of bioactivities. Among them, the imidazo(2,1-b)-benzothiazole derivatives are pharmacologically important because of their immunostimulant, anti-inflammatory, antifungal, antimicrobial, antitumor, and other activities. In the present research work, a novel series of 2,3-diaryl-substituted imidazo(2,1-b)-benzothiazoles 13a-o have been synthesized by reaction of substituted 2-aminobenzothiazoles 1-8 and an appropriately substituted a-bromo-1-(4″-substituted)-phenyl-2-(4′- substituted)-phenyl-1-ethanones 9-12 in the presence of anhydrous acetonitrile. They were characterized by physicochemical, elemental, and spectral (IR, 1H-NMR, and Mass) data. All the synthesized compounds were screened for their in-vitro antibacterial activity against Gram-positive, Gram-negative bacteria. The investigation of antibacterial screening data revealed that most of the compounds tested have demonstrated congruent activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa as compared with the standard ampicillin. Among the series, compounds 13d, 13h, and 13m exhibited excellent an antibacterial activity profile as compared with the standard. In summary, preliminary results indicate that some of the newly synthesized title compounds exhibited promising antibacterial activities and they warrant more consideration as prospective antimicrobials.