1240496-75-6

Basic information

• Product Name: 3-(8-(2,4-difluorophenyl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyridazin-3-yl)-4-methylbenzoic acid
• Synonyms: 3-(8-(2,4-difluorophenyl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyridazin-3-yl)-4-methylbenzoic acid
• CAS NO: 1240496-75-6
• Molecular Weight: 407.376
• Mol File: 1240496-75-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(8-(2,4-difluorophenyl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyridazin-3-yl)-4-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(8-(2,4-difluorophenyl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyridazin-3-yl)-4-methylbenzoic acid(1240496-75-6)
• EPA Substance Registry System: 3-(8-(2,4-difluorophenyl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyridazin-3-yl)-4-methylbenzoic acid(1240496-75-6)

Safety Data

• Hazardous Substances Data: 1240496-75-6(Hazardous Substances Data)

Upstream product

• 170230-88-3 3-carboxy-6-methylphenylboronic acid 
• 1210812-83-1 3-bromo-8-(2,4-difluorophenyl)-1-methylpyrido[3,2-d]pyridazin-2(1H)-one 

Downstream Products

• 1214882-42-4 3-(8-(2,4-difluorophenyl)-1-methyl-2-oxo-1,2-dihydropyrido[3,2-d]pyridazin-3-yl)-N,4-dimethylbenzamide 

Relevant articles and documents

Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors

The p38 mitogen-activated protein kinase (MAPK) plays an important role in the production of proinflammatory cytokines, making it an attractive target for the treatment of various inflammatory diseases. A series of pyridazinopyridinone compounds were designed as novel p38 kinase inhibitors. A Structure-activity investigation identified several compounds possessing excellent potency in both enzyme and human whole blood assays. Among them, compound 31 exhibited good pharmacokinetic properties and showed excellent selectivity against other related kinases. In addition, 31 demonstrated efficacy in a collagen-induced arthritis disease model in rats.