124052-92-2Relevant articles and documents
Process for the preparation of 5-hydroxy-3,4,5,6-tetrahydro-pyrimidine derivatives
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, (2008/06/13)
The invention relates to a new process for the preparation of 5-hydroxy-3,4,5,6-tetrahydro-pyrimidine derivatives of the general formula (I) STR1 in which R represents optionally substituted alkyl, which is characterized in that amidines of the general formula (II), STR2 in which R has the abovementioned meaning, are reacted with epichlorohydrin of the formula (III) STR3 if appropriate in the presence of a diluent at temperatures between 0° C. and 150° C.