124068-67-3

Basic information

• Product Name: C₁₅H₁₇ClN₂O₂
• CAS NO: 124068-67-3
• Molecular Weight: 292.765
• Mol File: 124068-67-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₇ClN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₇ClN₂O₂(124068-67-3)
• EPA Substance Registry System: C₁₅H₁₇ClN₂O₂(124068-67-3)

Safety Data

• Hazardous Substances Data: 124068-67-3(Hazardous Substances Data)

Upstream product

• 15513-16-3 N-cyclohexylpyridin-2-amine 
• 79-04-9 chloroacetyl chloride 

Relevant articles and documents

REACTIONS OF N-SUBSTITUTED 2-AMINOPYRIDINES WITH CHLOROACETYL CHLORIDE; FORMATION OF A NEW SERIES OF HETEROCYCLIC BETAINES: 1-SUBSTITUTED 4-CHLOROMETHYL-2-OXOPYRIDINOPYRIMIDIN-5-IUM-3-OLATES

N-(2-Pyridyl)-2-chloroacetamide reacted with 1-methylpiperazine and gave the expected compound III.Attempts at preparing the N-substituted N-(2-pyridyl)-2-chloroacetamides by reactions of N-substituted 2-aminopyridines with chloroacetyl chloride in benzene in the presence of N,N-dimethylacetamide were negative and took an unexpected course. 2-Anilinopyridine and 2-(cyclohexylamino)pyridine afforded compounds which were identified by 1H and 13C NMR spectra as the heterocyclic betaines IVa and IVb. 2-(1-Butylamino)pyridine, 2-(benzylamino)pyridine and 2-(2-phenylethylamino)pyridine gave similarly compounds IVc-IVe.The chloromethyl compounds IVa-IVe underwent normal substitution reactions with 1-methylpiperazine and gave the methylpiperazino compounds Va-Ve.Attempts to reduce the betaines with sodium borohydride in aqueous ethanol proceeded in one case as the hydrogenolytic displacement of the chlorine atom with hydrogen (product VIa), in another case as ethanolysis (product VIIb).Formation of VIb by treatment of IVb with hydrgen bromide in boiling acetic acid is probably the result of a disproportionation reaction.Compound III (dimaleate VUFB-17 103) was practically equipotent with pirenzepine (I) as an anti-ulcer agent in the test of indomethacine-induced gastric lesions in rats but was much weaker in tests for anticholinergic and antisecretory activity.