1240892-68-5

Basic information

• Product Name: C₁₉H₁₉NO₅
• Synonyms: C₁₉H₁₉NO₅
• CAS NO: 1240892-68-5
• Molecular Weight: 341.364
• Mol File: 1240892-68-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₉NO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₉NO₅(1240892-68-5)
• EPA Substance Registry System: C₁₉H₁₉NO₅(1240892-68-5)

Safety Data

• Hazardous Substances Data: 1240892-68-5(Hazardous Substances Data)

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 119035-03-9 5,6-dimethoxy-2-methoxycarbonylindan-1-one 
• 2107-70-2 3,4-methoxycinnamic acid 
• 51842-87-6 3-(3,4-dimethoxy-phenyl)-propionyl chloride 
• 2107-69-9 5,6-dimethoxy-1-indanone 

Downstream Products

• 1300115-99-4 C₁₉H₁₉NO₆ 

Relevant articles and documents

Synthesis and antitumor activity of aza-brazilan derivatives containing imidazolium salt pharmacophores

The synthesis of a series of novel aza-brazilan derivatives containing imidazolium salt pharmacophores is presented. The biological activity of such imidazolium salts was further evaluated in vitro against a panel of human tumor cell lines. The results suggest that the electron-withdrawing group on the aza-brazilan moiety, substituted 5,6-dimethyl-benzimidazole ring and substitution of the imidazolyl-3-position with a 4-methylbenzyl group were essential for modulating the cytotoxic activity. Compounds 55 and 39, bearing a 4-methylbenzyl substituent at position-3 of 5,6-dimethyl-benzimidazole, were found to be the most potent compounds with IC50 values of 0.52-1.30 μM and 0.56-1.51 μM against four human tumor cell lines investigated. Particularly, compound 57 exhibited inhibitory activity against the MCF-7 cell line with an IC50 value of 0.35 μM and was 56-fold more sensitive than DDP. Moreover, compound 55 inhibited cell proliferation through inducing G0/G1 cell cycle arrest and apoptosis in SMMC-7721 cells.

Synthesis of donepezil-based multifunctional agents for the treatment of Alzheimer's disease

Amyloid beta (Aβ) and cholinesterase enzymes (AChE, BuChE) are important biological targets for the effective treatment of Alzheimer's disease. In this study, the aim was to synthesize new donepezil-like secondary amide compounds that display a potent inhibition of cholinesterases and Aβ with antioxidant and metal chelation abilities. All test compounds showed activities against both ChEs and β1-42 inhibition. The most encouraging compound, 20, is an AChE inhibitor with high anti-aggregation activity (55.3%). Based on the results, compound 20 may be a promising structure in further research for new anti-Alzheimer's agents.